功能性多糖与家禽肠道黏膜免疫调控的构效关系  

Interactions between the Structure of Polysaccharides and Its Modulation on Intestinal Immune Responses in Poultry

作　　者：杨小军[1] 王筱霏[1] 尹瑞卿[1] 姚军虎[1] 

机构地区：[1]西北农林科技大学动物科技学院,杨凌712100

出　　处：《动物营养学报》2011年第7期1089-1093,共5页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家自然基金青年项目(31001017);陕西省自然基金(2010JQ3002);陕西省"13115"科技创新工程技术研究中心项目(2010ZDGC-02);动物营养学国家重点实验室项目(2004DA125184F0809);中央高校基本科研业务费专项资金(QN2009020)

摘　　要：本文旨在以家禽肠道黏膜免疫功能调控为着眼点,总结多糖生物学功能研究的最新进展,重点分析糖化学结构修饰与其生物学功能之间的关系,并对该领域今后的研究趋势和方向进行了分析。多糖可以增强家禽肠道黏膜免疫,并且适当的结构修饰能够增强其免疫活性,但由于多糖结构的复杂性及其研究技术的多样性使多糖构效关系的研究尚未成体系,需要进一步分析功能性多糖的定植位点和结构,构建多糖与分子靶标的构效关系及其下游信号通路。The purpose of the review is to summarize the relationship between the structure and function of polysaccharides.Focused on the intestinal mucosal immunomodulation in poultry and the prospects of the researches on polysaccharides,this article describes emphatically the new advances in biological function of polysaccharides.Polysaccharides can enhance the intestinal mucosal immune function in poultry.The biological activities of polysaccharides are increased by the appropriate modification.Because of the complexity and diversity of the structure of polysaccharides,there is still a further need for research in function sites and downstream signal pathways,and the relationship between the structure and immune function of polysaccharides.

关 键 词：功能性多糖 构效关系 肠道免疫 家禽 

分 类 号：S816.7[农业科学—饲料科学]