胸腺五肽治疗低复制状态慢性乙型肝炎的临床疗效  

Curative Effect of Thymopentin on Low Replicating Chronic Hepatitis B

作　　者：姜艳玲[1] 沈科书[1] 高雪娟[1] 李艳玲[1] 吴业红[2] 

机构地区：[1]吉林省肝胆病医院,长春市130062 [2]长春生物制品研究所生物技术研究室,长春市130062

出　　处：《中国生物制品学杂志》2011年第9期1084-1086,共3页Chinese Journal of Biologicals

基　　金：吉林省科技厅资助项目(04-07SF060)

摘　　要：目的观察胸腺五肽(Thymopentin,TP-5)治疗低复制状态慢性乙型肝炎的临床疗效。方法将72例HBV-DNA定量检测低于2 000 IU/ml的慢性乙型肝炎患者随机分为两组:治疗组(38例)经肌肉注射TP-5 1 mg,每日1次;对照组(34例)口服护肝片,每日3次。疗程为12周,治疗结束后随访12周。采用PCR法检测两组患者HBV-DNA水平,化学发光法检测乙肝血清标志物变化,全自动生化仪检测肝功能指标,放射免疫法检测肝纤维化指标。结果治疗组在治疗及随访结束后,HBV-DNA阴转率均明显高于对照组(P<0.05),治疗组治疗后肝功能指标和肝纤维化指标均得到明显改善(P<0.01或P<0.05),与对照组治疗后相比,差异也有统计学意义(P<0.05);两组HBsAg阴转率比较,差异无统计学意义(P>0.05)。结论 TP-5可促进低复制状态慢性乙型肝炎HBV-DNA转阴,改善受损肝脏功能,延缓肝纤维化进展。Objective To observe the curative effect of thymopentin（TP-5） on low replicating chronic hepatitis B（HB）.Methods Seventy-two chronic HB patients with HBV-DNA levels of less than 2000 IU / ml were divided into two groups.The 38 patients in trial group were injected i.m.with 1 mg of TP-5,once a day,while the 34 patients in control group were treated with Hugan Pian,an oral tablet,3 times a day.A course consisted of 12 weeks,after which the patients were followed-up for 12 weeks.The patients in two groups were determined for HBV-DNA level by PCR,for serum markers of HB by chemiluminescent immunoassay,for liver function indexes by full automatic biochemical analyzer,and for liver fibrosis indexes by RIA.Results The HBV-DNA negative conversion rates in trial group after treatment and follow-up were significantly higher than those in trial group（P 0.05）,The liver function and fibrosis function indexes in trial group after treatment were improved significantly as compared with those before teratment（P 0.01 or P 0.05）,and showed significant difference with those in control group（P 0.05）.However,no significant difference was observed in the HBsAg-negative conversion rates of the two groups（P 0.05）.Conclusion TP-5 promoted the negative conversion of HBV-DNA of patients with low-replicating,improved the function of injured liver and delayed the progress of liver fibrosis.

关 键 词：胸腺五肽 肝炎 乙型 慢性 低复制状态 

分 类 号：R512.62[医药卫生—内科学] R392-33[医药卫生—临床医学]