半量GnRH拮抗剂方案对IVF-ET控制性超促排卵(COH)的临床效果  

Clinical Efficacy of Half-dose GnRH Antagonist on Protocol during Controlled Ovarian Hyperstimulation (COH) for IVF-ET

作　　者：欧俊[1] 张慧琴[1] 朱旻[1] 佘立平[1] 松迪[1] 惠宁[1] 

机构地区：[1]第二军医大学附属长海医院生殖医学中心,上海200433

出　　处：《生殖与避孕》2011年第9期632-634,共3页Reproduction and Contraception

摘　　要：目的:探讨半量促性腺激素释放激素拮抗剂(GnRHA)方案对体外授精-胚胎移植(IVF-ET)超促排卵的临床结局。方法:回顾性分析272例行IVF-ET治疗的患者,半量GnRHA方案组(A组)共136个周期和GnRH激动剂(GnRHa)长方案组(B组)136个周期。比较2种控制性超促排卵(COH)方案的临床结局。结果:A组的Gn使用剂量、使用天数、获卵数、胚胎种植率和多胎率均小于B组(P<0.05),而受精率、卵裂率、优质胚胎形成率及临床妊娠率组间无统计学差异(P>0.05)。结论:对正常卵巢储备的患者COH后行IVF-ET结局而言,半量GnRHA方案可以取得与标准GnRHa长方案一样的效果,并可减少Gn的使用天数及剂量,减轻患者的负担。Objective： To explore the efficacy of half-dose GnRH-antagonist（GnRNA） on the outcome in patients undergoing controlled ovarian hyperstimulation（COH） for IVF-ET.Methods： A total of 272 patients who underwent IVF-ET were enrolled in this study.They were divieded into group A and group B acording to half-dose GnRHA protocol and GnRH agonist（GnRHa） long protocol,136 cycles per group.The duration of gonadotrophins（Gn） administration,the number of oocytes retrieved,fertilization rates,cleavage rates,the number of high quality embryo,pregnancy rates were recoreded.Results： There was no significant difference in the fertilization rates as well as the cleavage rates,the number of high quality embryo,pregnancy rates between the two groups.Group A has a significantly lower probility in the duration and dose of gonadtrophine as well as the number of oocytes retrieved,embryo quality,multiple birth rate and implantation rate than those in group B.Conclusion： The half-dose GnRHA protocol works as well as GnRHa long protocol for patients with normal ovarian function undergoing COH in IVF-ET treatmen.Moreover,it can also reduce the duration and dose of Gn and the burden of the patients.

关 键 词：GnRH拮抗剂(GnRHA) GnRH激动剂(GnRHa) 体外受精-胚胎移植(IVF-ET) 

分 类 号：R714.8[医药卫生—妇产科学]