氟比洛芬酯对预防不同年龄段患者丙泊酚静脉注射痛的疗效分析  

Therapeutic effect of flurbiprofen pretreatment on the intravenous injection pain induced by propofol in patients of different ages

作　　者：石嵩[1] 李天佐[1] 

机构地区：[1]首都医科大学附属北京同仁医院麻醉科,北京100730

出　　处：《解放军医学杂志》2011年第9期983-984,994,共3页Medical Journal of Chinese People's Liberation Army

基　　金：北京市科委课题项目(Z101107050210030)

摘　　要：目的观察预先注射氟比洛芬酯对不同年龄段患者丙泊酚静脉注射痛的影响。方法 120例全麻下择期手术的患者,按年龄分为3组：6~18岁（少儿组）,18~60岁（成年组）及60岁以上（老年组）,每组40例。各年龄组又随机分为两个亚组：氟比洛芬酯组和对照组（n=20）。氟比洛芬酯组静脉注射1.0mg/kg氟比洛芬酯,对照组静脉注射生理盐水5ml。随后开始静脉全麻诱导,1.5~2.0mg/kg丙泊酚静脉推注,20s后,1.5~2.0mg/kg氯化琥珀胆碱静脉推注。记录诱导静脉推注时肢体逃避和不适主诉的发生情况及程度。结果在各年龄组,氟比洛芬酯组静脉诱导时肢体疼痛、躲避反应及不适主诉的发生率和严重程度明显低于对照组,差异有统计学意义（P〈0.05）。对照组中丙泊酚静脉注射痛的发生率为少儿组82.0%、成年组47.9%、老年组28.0%。氟比洛芬酯组丙泊酚静脉注射痛发生率为少儿组8.8%、成年组11.2%、老年组4.7%,较对照组明显降低（P〈0.05）。结论预先注射氟比洛芬酯可明显减少不同年龄段患者丙泊酚静脉注射痛的发生。Objective To evaluate the therapeutic effect of flurbiprofen pretreatment on the pain induced by propofol in patients of different ages.Methods One hundred and twenty patients with different age and undergoing general anesthesia were assigned to three groups（40 each） according to their ages： 6-18 years（adolescent） group,18-60 years（adult） group,and over 60 years（aged） group.Each group was randomly divided into two subgroups（20 each）： flurbiprofen group and placebo group,and they respectively received intravenous injection of 5ml of 1mg/kg flurbiprofen（group FB） or normal saline（group NS）.The induction was produced by 1.5-2mg/kg Ⅳ propofol,and 1.5-2.0mg/kg Ⅳ succinylcholine was administered 20 seconds after propofol injection.Patients＇ withdrawal movements,pain scores and any other discomfort complaints were assessed.Results The incidences of intravenous pain in group NS and group FB were respectively 47.9% and 11.2% in adult group,82.0% and 8.8% in adolescent group,and 28.0% and 4.7% in aged group.The incidence of withdrawal movements and pain scores were significantly lower in flurbiprofen group than in saline group regardless of ages（P0.05）.Conclusion The pretreatment with 1.0mg/kg flurbiprofen may reduce the withdrawal movements and pain caused by propofol injection in patients of different age.

关 键 词：氟比洛芬酯 注射痛 二异丙酚 诱导 逃避反应 

分 类 号：R614.2[医药卫生—麻醉学]