大黄虫丸对阿霉素肾病大鼠肾保护作用的实验研究  

EXPERIMENTAL STUDY ON PROTECTIVE EFFECT OF DAHUANG ZHECHONG PILL ON KIDNEYS OF RATS WITH NEPHROPATHY INDUCED BY ADRIAMYCIN

作　　者：陈继红[1] 孙伟[1] 周栋[1] 高坤[1] 王跃娟[1] 

机构地区：[1]江苏省中医院肾病内科,南京210029

出　　处：《中国中医药科技》2011年第5期385-386,368,共2页Chinese Journal of Traditional Medical Science and Technology

摘　　要：目的:探讨大黄虫丸对阿霉素肾病大鼠的肾保护作用。方法:SD大鼠一次性尾静脉注射阿霉素(5mg/kg)复制肾病模型,随机分为模型组和大黄虫丸组(中药组),另以6只正常大鼠作为正常对照组,进行对比观察。实验第28天,大鼠检测尿蛋白及尿NAG酶后,全部处死,颈动脉取血检测血清尿素氮(BUN)、血肌酐(SCr)、白蛋白(ALB)、胆固醇(TC)、甘油三酯(TG)水平及血液流变学指标,取肾脏观察大鼠肾组织病理形态学变化。结果:中药治疗组大鼠尿蛋白、尿NAG酶含量、血胆固醇水平均明显降低,与模型组相比有统计学意义(P<0.05);血液高凝状态改善,红细胞刚性指数、全血低切还原黏度水平下降,与模型组相比,有显著性差异(P<0.05);肾脏病理损害减轻。结论:大黄虫丸能够降低蛋白尿、降低血脂水平、改善血黏度,对阿霉素所致的肾损害具有一定的保护作用。Objective:To discuss the protective effect of dahuang zhechong pill on kidneys of rats with nephropathy induced by adriamycin.Methods:Models were built by injecting adriamycin,models were divided into model,dahuang zhechong pill groups,taking normal rats as control group.Each group was given the corresponding management for 28 days,determined urine protein and NAG enzyme,than killed rats,determined blood BUN,SCr,ALB,TC,TG and rheology;taking renal tissue to observe pathomorphology changes.Results:Dahuang zhechong pill could reduce the urine protein and NAG enzyme of rats with nephropathy induced by adriamycin,decrease TG level,significantly improve hypercoagulability,ease the pathomorphology changes of renal tissue.Conclusion:Dahuang zhechong pill can protect rats' kidneys from adriamycin injury by lowering urine protein and blood lipid,improving blood coagulation.

关 键 词：肾病/中医药疗法 大黄 虫丸/治疗应用 肾病/病理学 大鼠 

分 类 号：R285.5[医药卫生—中药学]