硫化氢对两肾一夹模型所致大鼠心脏损害的作用  

The Effects of Hydrogen Sulfide on Rat Heart Damage Caused by Two-kidney and One-clip

作　　者：郑锦滨[1] 王东明[1] 

机构地区：[1]汕头大学医学院第一附属医院心血管内科,广东汕头515041

出　　处：《汕头大学医学院学报》2011年第3期153-155,共3页Journal of Shantou University Medical College

摘　　要：目的:研究硫化氢(H2S)在大鼠两肾一夹(2K1C)模型所致的心脏损害中的作用。方法:实验分为对照组、假手术组、2K1C模型组、2K1C+H2S组,建立大鼠2K1C模型,激活循环以及局部的肾素-血管紧张素系统,引起心脏损害。通过测定收缩压(SBP)、心脏指数来观察各组心脏形态变化。结果:H2S能明显降低SBP(P<0.001),改善心脏指数(P<0.001)。结论:H2S能明显改善由2K1C模型引起的心脏损害。Objective： To investigate the effects of hydrogen sulfide（ H2S） on rat heart damaged caused by two-kidney and one-clip（2K1C）. Methods： The rats were divided into control group, sham group, 2K1C model group and 2K1C ＋ H2S group. The renin-angiotensin system was activated by 2K1C to cause the heart damage. The systolic blood pressure （SBP） and the cardiac index were determined to observe the change of the rat heart. Results： H2S could significantly degrade the SBP（ P 〈 0.001）and improve cardiac index（ P 〈 0.001）. Conclusion： H2S can obviously improve the heart damage caused by 2K1C model.

关 键 词：硫化氢 两肾一夹模型 心脏损害 

分 类 号：R541.4[医药卫生—心血管疾病]