鼻咽癌组织ki67表达与外周血NK细胞的关系及意义  

Relationship between Expression of Ki-67 Protein and NK Cell of Peripheral Blood

作　　者：韦祝新[1] 李萍[2] 王仁生[1] 康敏[1] 胡凯[1] 

机构地区：[1]广西医科大学第一附属医院放疗科 [2]广西医科大学第一附属医院病理科,广西南宁530021

出　　处：《现代生物医学进展》2011年第18期3531-3533,共3页Progress in Modern Biomedicine

基　　金：广西壮族自治区卫生厅医疗卫生科研课题;Z2003052

摘　　要：目的:研究鼻咽癌组织Ki67的表达及外周血NK细胞水平的意义。方法:检测66例鼻咽癌组织Ki67水平及与外周血NK细胞的百分含量。结果:Ki67表达阳性率为96.97%,与临床分期有关(r=0.290,P=0.030<0.05),与淋巴结转移状态相关性在统计学上无意义(r=0.068,P=0.412>0.05);放疗前中后鼻咽癌外周NK细胞水平差别均有统计学意义(前中、中后、前后F=0.513,0.627,0.623,P分别为0.005,0.004,0.000,均<0.05);ki67的表达与放疗后NK细胞NK值负相关(r=-0.433,P=0.017<0.05)。结论:Ki67的表达可能与临床分期有关,可能与放疗后NK值有关;Ki67表达与外周血NK细胞水平可以提示鼻咽癌组织增殖活跃程度和机体防御系统的状态。Objective： To investigate relationship between expression of Ki-67 protein and NK cell of peripheral blood. Methods： We detected Ki67 level of NPC tissue and NK cell percentage composition of peripheral blood in 66 NPC cases. Results： The positive rate of Ki-67 in was 96.97%, The expression intensity of Ki-67 had significant relation with the clinical stage of NPC （r=0.290, P=0. 030〈0.05） and no significant relation with metastasis state of lymph （r=0.068,P=0.412〉0.05）. There are significance differences in the level of NK cell of peripheral blood either before or underway or after radiotherapy of NPC（ the seperated F values of front part, rear part and middle part are 0.513,0.627,0.623 and the counterparts of P values are 0.005,0.004,0.000, all of which are less than 0.05）. The expression intensity of Ki-67 had Negative correlation with the NK cell of peripheral blood. Conclusion： The expression intensity of Ki-67 may be related with clinical stage and NK level after radiotherapy, expression of Ki-67 protein and NK cell in peripheral blood may indicate proliferation activity of NPC tissue and status of body defense.

关 键 词：鼻咽癌 KI67基因 NK细胞 

分 类 号：R739.63[医药卫生—肿瘤]