血清表皮生长因子检测在类风湿关节炎患者中的临床研究  

Clinical significance of detecting serum epidermal growth factor Level in patients with rheumatoid arthritis

作　　者：张斌国[1] 栾清欣[1] 

机构地区：[1]山东省青岛市市立医院检验科,266011

出　　处：《中国实用医药》2011年第25期16-18,共3页China Practical Medicine

摘　　要：目的通过检测类风湿关节炎(RA)患者血清中表皮生长因子(EGF)的水平,探讨其在RA发病过程中存在的意义。方法将研究对象分为RA组和健康对照组,用酶联免疫吸附试验(ELISA)测定两组血清中EGF水平。同时测定RA患者的类风湿因子(RF)、红细胞沉降率(ESR)和C反应蛋白(CRP)。用统计学分析EGF在各组血清中的变化及其与临床各项指标间的相关性。结果 RA组血清EGF水平较正常对照组显著升高(P<0.05)。骨质破坏组血清EGF水平较单纯骨质疏松组显著升高(P<0.05)。RA组EGF水平与RF,ESR,CRP水平比较无显著相关性(P>0.05)。结论血清EGF水平在RA组明显升高,在骨质破坏组尤为明显。提示EGF在诊断RA中有一定价值,可能部分地参与RA的发病过程。Objective To detect the serum levels of epidermal growth factor （EGF）in rheumatoid arthritis（RA） patients, and explore the possible role of EGF in RA. Methods All the cases were individed into two groups： RA patients group and healthy control group. The serum level of EGF was measured by enzymelinked irmnunosorbent assay （ELISA）. Rheumatoid factor （RF）, erythrucyte sedimentation rate （ESR） and C-creative protein（CRP）were also measured in these RA patients. The relation beween the serum level changes of EGF and the corresponding clinical indexes in the two groups was statistically analyzed. Results Compared with the healthy individuals, the serum EGF levels of RA patients increased significantly （P 〈 0. 05 ）. Compared with simple bone rarefaction patients, the serum levels of EGF increased significantly in the bone erosion patients（P 〈 0. 05）. The serum levels of EGF in RA patients had no correlation with RF,ESR and CRP levels（P 〉0. 05）. Conclusion The evident increase of serum EGF level in RA patients, especially in bone erosion patients, suggests that EGF has some value in the diagnosis of RA and may partly play a role in the pathogenesis of RA.

关 键 词：关节炎 类风湿 表皮生长因子 

分 类 号：R593.22[医药卫生—内科学]