应用低氧运动时动脉血症和通气反应指标预测急性高原反应的探索研究  

Prediction of Susceptible to Acute Mountain Sickness by Hypoxemia and Ventilatory Response during Hypoxic Exercise

作　　者：徐飞[1] 胡扬[2] 

机构地区：[1]浙江工业大学体育科学研究所,浙江杭州310023 [2]北京体育大学,北京100084

出　　处：《体育科学》2011年第10期59-66,共8页China Sport Science

基　　金：北京市教委重点实验室开放性课题

摘　　要：目的:通过测试运动时低氧血症和低氧通气指标的变化来探索预测急性高原反应(actue mountain sickness,AMS)的可行性指标,为降低高原旅居人群罹患AMS的风险和提高其生活质量提供参考。方法:23名普通男性大学生于低氧舱(～4 400m,FIO211.8%～11.6%)暴露6h,分别于低氧暴露第0.5h、2h、4h和6h评测受试者急性高原反应(LLS量表),有头痛症状且LLS评分≥3者,定为AMS组。受试者进舱休息30min后进行30min运动心肺功能测试:于卧式功率车上安静5min后以80W恒定负荷(60rpm)仰卧蹬车20min,恢复5min。每5min末记录RPE、HR、SpO2、BP和低氧通气反应相关指标。据测试指标计算AMS组和nonAMS组低氧通气指数和低氧心功能指数差异。取有显著性差异的指标作为自变量与LLS评分拟合得出预测方程。结果:急性低氧暴露结束时AMS发生率为27%。低氧安静时AMS组与nonAMS组RPE、HR、SpO2、VE、VT和fR无显著性差异。低氧运动时AMS组SpO2显著低于nonAMS组(P<0.05),运动5min时达最低点。低氧运动5min时AMS组VE显著低于nonAMS组(分别为41.4±4.6 1/min和46.7±4.6l/min,P<0.05)。低氧运动时SpO2和VE预测LLS评分的非线性方程分别为:LLS=0.0295(SpO2)2-4.5269(SpO2)+174.34(R2=0.7473,P<0.001)和LLS=0.0352(VE)2-3.4987(VE)+87.729(R2=0.307,P=0.053);SpO2与VE呈中度相关(R=0.394,P<0.05)。结论:低氧运动时动脉血症指标SpO2和通气指标VE可作为预测AMS的有效指标,SpO2的预测准确性高于VE,运动时SpO2与VE呈中度相关。从测试的简便、可靠角度考虑,运动时SpO2的变化具有较好的应用前景。Objective： To explore predictable of parameters of acute mountain sickness （AMS） by hypoxemia and hypoxic ventilatory response during hypoxic exercise, so as to supply some references to reduce the risks of AMS and improve life quality of altitude travelers. Methods： Recruit 23 male students in hypoxia chamber （-4400 m,F1O2 11.8%-11.6%） exposure 6 hours, and record the participants ＇ AMS （LLS score） in 0. 5,2,4 and 6 h. When participants＇ LLS ≥3 and with headache symptom defined as AMS group. After rest 30 min in hypoxia chamber, participants experienced 30 min cardiopulmonary test （supine exercise with 80 W, 60 rpm）, record RPE, HR, SpO2, BP and hypoxic ventilatory response every 5 min, and calculate the hypoxic ventilatory and cardio function response indexes according aforementioned parameters. After test procedure, take the significant difference indexes as independent variables fit non-linear predictable equations. Results：After 6 h exposure, the incidence of AMS is 27 %. There is no significant difference in RPE, HR, SpO2, VE, VT and fR between the AMS and non AMS group when participants rest in hypoxic chamber. However, the SpO2 of AMS group is significant lower than non AMS group （P〈0.05 ）, the lowest value observed in exercise 5 min. In addition, the VE of AMS group is significant lower than non AMS group （41.4 ±4. 6 and 46.7±4. 6 1/min, P〈0.05, respectively）. The predictable equations are LLS= 0.0295（SPO2）2- 4.5269（SpO2）q-174. 34（R2=0. 7473,P〈0. 001） and LLS=0.0352 （VE）^2 - 3. 4987（VE）-87. 729（R^2 =0. 307,P=0. 053） ,respectively. And SpO2 is moderately correlated with VE （R = 0. 394, P〈 0. 05）. Conclusions： The changes of hypoxemia （SpO2） and hypoxic ventilatory response （VE） during hypoxic exercise can be use as effective indicators of AMS. The predictable accuracy of SpO2 is better than VE, and there is a moderately correlation between SpO2 and VE. From the perspective of test simple and reliable, the change of SpO2 du

关 键 词：急性高原反应 低氧运动 低氧血症 动脉血氧饱和度 低氧通气反应 

分 类 号：G804.2[文化科学—运动人体科学]