玫瑰花中抗补体活性成分研究  

Study on Anticomplement Activity of Extracts from Flowers of Rosa rugosa

作　　者：杨庆雄[1] 张万全[2] 余天华[2] 孙黔云[3] 

机构地区：[1]贵州师范大学化学与材料科学学院,贵州贵阳550001 [2]贵州师范大学生命科学学院,贵州贵阳550001 [3]中国科学院天然产物化学重点实验室,贵州贵阳550002

出　　处：《安徽农业科学》2011年第26期15962-15964,共3页Journal of Anhui Agricultural Sciences

基　　金：国家自然科学基金项目(30860038);贵州省科技厅科技基金项目(黔科合J字[2009]2090号);国家重大基础研究(973计划)前期研究专项(2007CB516813)

摘　　要：[目的]分离鉴定玫瑰(Rosa rugosa)花中的抗补体活性成分。[方法]在活性筛选指导下,并用多种色谱方法进行分离纯化,并用核磁共振、质谱数据与文献数据对比鉴定化合物结构。[结果]从活性部位中分离出3个黄酮类化合物,分别为木犀草素(1)、槲皮素(2)和山柰酚(3)。[结论]玫瑰花提取物有体外抗补体作用,其中黄酮类化合物是其活性成分。[Objective] The aim was to isolate and identify the anticomplement constituents in the flowers of Rosa rugosa.[Method] Under the guidance of activity screening,many chromatographic processes were used to isolate and purify,moreover,structures of compounds were identified through comparing nuclear magnetic resonance（NMR） and mass spectrometric data（MS） with literature data.[Result] Three kinds of flavonoids compounds were isolated from active sites,and they were identified as luteolin（1）,quercetin（2） and kaempferol（3）,respectively.[Conclusion] The extracts of the flowers of Rosa rugosa showed anticomplement activity,due to the flavonoids in the extracts.

关 键 词：玫瑰花 抗补体活性 木犀草素 槲皮素 山奈酚 

分 类 号：S685.12[农业科学—观赏园艺]