血清半胱氨酸蛋白酶抑制剂C在老年高血压患者的临床应用  

Clinical application of serum cystatin C in aged patients with hypertension

作　　者：沈丹[1] 曹萍[1] 王桦[1] 韩艳萍[1] 钟亚[1] 

机构地区：[1]武汉大学中南医院综合医疗科,湖北武汉市430071

出　　处：《心血管康复医学杂志》2011年第5期489-491,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨检测血清半胱氨酸蛋白酶抑制剂C(Cys C)在不同级别及危险分层的老年高血压检测中的意义。方法:随机选择老年高血压病患者112例,进行分级和危险分层后,采用酶联免疫法(ELISA)测定血清Cys C水平,并测定血清尿素氮(BUN)、肌酐(Cr)浓度。结果:在1级高血压患者中血清Cys C的阳性率为40%,显著高于血清BUN(6.7%)、Cr(6.7%)的阳性率(Ρ均<0.05);随着患者血压水平的升高,以及危险分层的增加,血清Cys C水平呈逐级、逐层渐进性升高(Ρ<0.05或<0.01),其显著性甚于BUN、Cr;并且血清Cys C与高血压危险分层之间存在直线回归关系(r=0.508,Ρ<0.01)。而只有当高血压达到3级或极高危时,才有血清BUN、Cr水平的显著变化(Ρ<0.05或<0.01)。结论:在老年高血压患者中检测血清半胱氨酸蛋白酶抑制剂C有助于发现早期肾功能损害,可能对患者的预后判定有一定的临床意义。Objective： To explore significance of detection of serum cystatin C （Cys C） in aged hypertensive patients with different stages and risk stratifications. Methods： A total of 112 aged cases with essential hypertension were selected randomly and divided into three stages and four risk stratification. Enzyme linked immunosorbent assay （ELISA） was used to measure serum Cys C level. Serum concentrations of blood urea nitrogen （BUN） and creatinine （Cr） were measured by automatic biochemistry analyzer. Results： Positive rate of serum Cys C was 40G in patients with hypertension stage 1, and significantly higher than those of serum BUN （6.7 %） and Cr （6.7 %）, P〈0.05 hoth; as level of blood pressure and risk stratification increased, serum Cys C level increased gradually （P〈0.05 or〈0.01）, and more than those of BUN and Cr. Linear regression analysis showed serum Cys C level was correIation with risk stratification of hypertension （r= 0. 508, P〈0.01）. Serum levels of BUN and Cr significantly changed only in patients with hypertension stage 3 or extreme high risk stratification （P〈0.05 or P〈0.01）. Conclusion： Detection of serum cystatin C contributes to identify early impaired renal function in aged patients with hypertension. Its level may be used to determine the prognosis of patients.

关 键 词：半胱胺酸蛋白酶抑制剂C 高血压 老年人 

分 类 号：R544.1[医药卫生—心血管疾病]