左金丸传统汤剂、复方颗粒剂、配方颗粒剂吴茱萸碱及吴茱萸次碱的含量比较  

Comparison the Content of Evodiamine and Rutaecarpine from Compatible Granule,Compound Granule and Traditional Decoction of Zuojin Pills

作　　者：张欣[1] 靳凤云[1] 梁光义[1,2] 贺祝英[1] 章誉[1] 

机构地区：[1]贵阳中医学院,贵阳550002 [2]贵州省中国科学院天然产物化学重点实验室,贵阳550002

出　　处：《中国实验方剂学杂志》2011年第19期67-71,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然基金项目(30860364)

摘　　要：目的:比较左金丸传统汤剂、复方颗粒剂与配方颗粒剂中吴茱萸碱和次碱的含量差异。方法:采用HPLC测定传统汤剂、复方颗粒剂、配方颗粒剂中吴茱萸碱和吴茱萸次碱的含量,并对含量测定的方法进行了考察。结果:HPLC测定吴茱萸碱和次碱在传统汤剂中总质量分数为0.738 0 mg.g-1,在复方颗粒剂中总质量分数为1.379 0 mg.g-1,在配方颗粒剂中总质量分数为0.225 9 mg.g-1。结论:左金丸传统汤剂、复方颗粒剂、配方颗粒剂吴茱萸碱和吴茱萸次碱总质量分数差异较大:复方颗粒剂>传统汤剂>配方颗粒剂。Objective：To compare the content of evodiamine and rutaecarpine from traditional decoction,compound granules and granule formulation in the Zuojin pills.Method： The content of evodiamine and rutaecarpine in the three forms of Zuojin pills was determined and the method to determine content was established by HPLC.Result： There is 15.455 3 mg·g-1 evodiamine and rutaecarpine in the traditional decoction,21.792 4 mg·g-1 in the compound granules,26.648 3 mg·g-1 in the formulation granules.Conclusion：There are significant differences in the three forms of Zuojin pills.The order is formulation granulescompound granulestraditional decoction.

关 键 词：高效液相色谱 左金丸 传统汤剂 复方颗粒剂 配方颗粒剂 吴茱萸碱 吴茱萸次碱 

分 类 号：R284.1[医药卫生—中药学]