人参及其炮制品抗疲劳作用  

Anti-fatigue Effects of Ginseng and Its Processed Products

作　　者：高伟博[1] 米钧[1] 秦秋杰[1] 孙靖辉[1] 吴巍[1] 王淑敏[1] 刘淑莹[1,2] 

机构地区：[1]长春中医药大学,吉林省人参科学研究院,长春130117 [2]中国科学院长春应用化学研究所,长春130022

出　　处：《中国实验方剂学杂志》2011年第19期210-213,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：吉林省科技发展重大项目(20086043,20096043)

摘　　要：目的:研究人参及其炮制品在抗疲劳中的作用。方法:昆明种雄性小鼠120只,随机分组,分别为人参、红参、高压红参提取物高、中、低剂量(5,2.5,1.25 g.kg-1)组和空白对照组,连续ig给药15 d。小鼠经负重游泳后,检测肝糖元、肌糖元、血尿素氮、血乳酸含量、超氧化物歧化酶和乳酸脱氢酶6种与疲劳作用相关的生物化学指标。结果:实验组与对照组相比,人参组小鼠肝糖元(11.33±3.45)g.kg-1(P<0.01)、肌糖元(1.982±0.83)g.kg-1(P<0.05)含量升高;血尿素氮(29.71±6.42)g.L-1(P<0.05)、血乳酸(8.70±2.03)mmoI.L-1(P<0.05)含量降低;红参组小鼠肝糖元(10.46±3.21)g.kg-1(P<0.01)含量升高,血尿素氮含量(29.45±5.06)g.L-1(P<0.05)降低;高压红参组小鼠肝糖元(9.87±2.44)g.kg-1(P<0.01)含量升高。结论:人参和2种炮制品均具有抗疲劳作用,其中以人参效果最为显著,这为开发人参功能性食品和药物提供了理论依据。Objective：To observe the anti-fatigue effects of ginseng and its processed products.Method： One hydred and twenty mice were allocated randomly into ginseng,red ginseng and red ginseng processed by high pressure groups.Each treatment was divided into three subgroups by dosages（5,2.5,1.25 g·kg-1）.Blank control group was treated with 0.9%NaCl.Drugs were administered to mice for 15 days,then fatigue-related biochemical indicators were analyzed.Result： Compared with the control group,the mice of ginseng group had a higher content of liver glycogen（11.33±3.45）g·kg-1（P0.01）and muscle glycogen（1.98±0.83）g·kg-1（P0.05）,and lower content of blood urea nitrogen（BUN）（29.71±6.42）g·L-1（P0.05）;the mice of red ginseng group had a higher content of liver glycogen（10.46±3.21）g·kg-1（P0.01）,and lower content of BUN（29.45±5.06）g·L-1（P0.05）;the mice of high pressure red ginseng group had a higher content of liver glycogen（9.87±2.44）g·kg-1（P0.01）.Conclusion：All the three types of ginseng showed anti-fatigue effects.

关 键 词：抗疲劳 人参 红参 高压红参 

分 类 号：R285.5[医药卫生—中药学]