降防保心胶囊对原发性高血压患者血管内皮细胞功能紊乱的调节作用  

Regulation of Jiangfang Baoxin Capsule to Vascular Endothelial Cell Dysfunction in Essential Hypertension Patients

作　　者：张志斌[1] 陆曙[2] 周春刚[1] 

机构地区：[1]无锡市中医医院心血管病实验室,江苏无锡214001 [2]无锡市中医医院心内科,江苏无锡214001

出　　处：《中国实验方剂学杂志》2011年第19期254-257,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：江苏省中医药科研课题(LZ03001)

摘　　要：目的:研究降防保心胶囊对高血压病患者血管内皮细胞(VEC)功能紊乱的调节作用。方法:原发性高血压患者62例随机分为对照组30例和中药干预组32例,分别采用标准治疗和加用降防保心胶囊(口服每次3粒,每日3次)治疗3个月,观察治疗前后各组血压和外周血中一氧化氮(NO)、一氧化氮合酶(NOS)、诱导型一氧化氮合酶(iNOS)、内皮素(ET-1)和血管紧张素II(AngII)水平的变化。结果:中药干预组治疗后NO水平和NO/ET-1均显著升高(P<0.05),ET-1水平显著降低(P<0.05),NOS,iNOS,AngII水平则均无显著差异;对照组NO,ET-1,AngII水平,NO/ET-1在用药前后均无显著差异,NOS,iNOS水平则在治疗后均显著降低(P<0.01);治疗后的NO水平,NOS,iNOS水平和NO/ET-1,中药干预组均显著高于对照组(P<0.01)。结论:降防保心胶囊具有纠正原发性高血压(EH)患者VEC功能障碍、保护VEC功能的作用,在预防和遏制高血压引起的血管病变、降低与高血压有关的心脑血管意外方面可能具有潜在的重要作用。Objective：To research the regulation of Jiangfang Baoxin capsule to vascular endothelial cell function disorder in essential hypertension patients.Method： Sixty-two essential hypertension patients were rando mLy divided into two groups：control group（30 cases）and herb intervention group（32 cases）,which were treated with standard therapy and additional Jiangfang Baoxin capsule（orally ter daily,3 capsules each time）respectively for 3 months.The changes of blood pressure and levels of nitric oxide（NO）,nitric oxide synthase（NOS）,inducible nitric oxide synthase（iNOS）,endothelin（ET-1）and angiotention II（AngII）from peripheral blood of the two group patients were compared.Result：After treatment,NO level and NO/ET-1 ratio of herb intervention group was significantly increased than before（P0.05）,while ET-1 dose significantly decreased（P0.05）,and the levels of NOS,iNOS,ET-1 and AngⅡ had no difference;In control group,there was no difference of the values of NO,ET-1,AngII and NO/ET-1 ratio between before and after treatment,and the levels of NOS and iNOS were significantly decreased through the treatment（both P0.01）;After treatment,values of NO,NOS,iNOS and NO/ET-1 ratio of herb intervention were all significantly higher than those of control group（P0.01）.Conclusion：Jiangfangbaoxin capsule could correct（vascular endothelial cell,VEC） function obstacle and protect VEC function of essential hypertension patients.

关 键 词：降防保心胶囊 原发性高血压 血管内皮细胞功能 

分 类 号：R287[医药卫生—中药学]