合成噬菌体的贡献与风险  

Contribution and risk of synthetic bacteriophage

作　　者：赵向娜[1] 杨瑞馥[1] 

机构地区：[1]军事医学科学院微生物流行病研究所,病原微生物生物安全国家重点实验室,北京100071

出　　处：《生命科学》2011年第9期917-920,共4页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(30930001)

摘　　要：噬菌体(bacteriophage,phage)是感染细菌、真菌、放线菌或螺旋体等微生物的细菌病毒的总称。噬菌体在生态、微生物进化、细菌性疾病预防和治疗、细菌鉴定与疾病诊断等方面扮演重要角色。基因组测序技术和高效合成平台促进了合成基因组学的发展。利用合成基因组学技术,对噬菌体基因组进行设计或者合成出新的噬菌体来服务人类在不久的未来可能成为现实。但与此同时,合成噬菌体带来的风险也必须认真考虑。Phages are viruses, which infect bacteria, fungi, actinomycetes, spiral bacteria and other microorganisms. Phages play an important role in ecology, microbial evolution, prevention and treatment of bacterial diseases, bacterial identification and disease diagnosis etc. Genome sequencing technology and efficient synthesis platform promote the development of synthetic genomics. Designing phage genomes or synthetizing novel phages to serve human with synthetic genomics technology could become a reality in the near future. Meanwhile, risks brought by svnthetic phage must be considered seriously.

关 键 词：噬菌体 合成基因组学 细菌性疾病 

分 类 号：O621.33[理学—有机化学] Q939.48[理学—化学]