对阿莫西林和克拉霉素耐药的幽门螺杆菌感染患者的临床方法探讨  

THE ANALYSIS OF THE CLINICAL EFFECT TO THE PATIENTS INFECTED BY HEFICOBACTER PALORI AMOXICILLIN AND CLARITHROMYCIN

作　　者：李锐[1] 陈燕[1] 郝素云[1] 葛海燕[1] 

机构地区：[1]武警医学院附属医院,天津300162

出　　处：《现代预防医学》2011年第20期4279-4280,共2页Modern Preventive Medicine

摘　　要：[目的]探讨对阿莫西林和克拉霉素耐药的幽门螺杆菌感染患者的治疗手段,以寻找一种有效的治疗方法。[方法]回顾性分析我院100例幽门螺杆菌感染者的不同治疗方案的治疗结果。入选患者分别接受(A组)质子泵抑制剂(咯赛克20mg,1次/d)+左氧氟沙星胶囊(0.2,3次/d)+呋喃唑酮(0.1,3次/d)和(B组)质子泵抑制剂(咯赛克20mg,1次/d)+甲硝唑(0.2,3次/d)+庆大霉素针(8万U,3次/d,po)治疗2W,1月后复查快速尿素酶试验。[结果]A组(左氧氟沙星组)Hp清除率为74%,B组(甲硝唑组)为50%,两组幽门螺杆菌清除率比较差异有统计学意义(P﹤0.05)。[结论]质子泵抑制剂联合左氧氟沙星胶囊及呋喃唑酮具有杀菌率高、不良反应小等优点,建议上作为对阿莫西林和克拉霉素耐药的幽门螺杆菌感染患者首选用药组合。[Objective] To analyze and compare the clinical effect to the patients infected by helicobaetcr palori （Hp） that were unsuccessful treated by Amoxieillin and Clarithromyein that could be the better program. [ Methods] The patienrs were divided into two groups. Group A received Omeprazole ＋ Levofloxacin ＋ Furazolidone for two weeks. Group B received of Omeprazole ＋ Metronidazole＋ Gentamycin for two weeks. One month later, all the patients were examined Hp by the electron coronoseope. [Results] The Hp of 74% patients were eradicated in the Levofloxacin group （Group A） and that in the Group B were only 50%. The statistics result showed the significant difference between the two groups （P 〈 0.05）. [ Conclusion ] The effect of Omeprazole ＋ Levofloxacin ＋ Furazolidone to the Hp was better than the that of Omeprazole ＋ Metronidazole＋ Gentamycin. So we suggested using Amoxicillin and Clarithromycin in eradicating the Hp infection.

关 键 词：克拉霉素 阿莫西林 幽门螺杆菌 临床治疗 

分 类 号：R975[医药卫生—药品]