艾片的大鼠在体肠吸收动力学研究  

Study on the Intestinal Absorption Kinetics of Aipian in Rats

作　　者：马勇[1] 杜守颖[1] 宋逍[1] 陆洋[1] 李冬雪[2] 

机构地区：[1]北京中医药大学中药学院,北京市100102 [2]中国生物技术发展中心,北京市100036

出　　处：《中国药房》2011年第39期3651-3653,共3页China Pharmacy

基　　金：国家科技重大专项课题(2009ZX09502-008;2009ZX09308-003);高等学校博士学科点专项科研基金(20090013110007)

摘　　要：目的:研究艾片的大鼠在体肠吸收动力学。方法:采用大鼠在体单向灌流实验,利用气相色谱法测定艾片中龙脑含量,分别研究灌流流速、药物浓度、吸收部位对艾片吸收的影响。结果:灌流流速、药物浓度、吸收部位对艾片吸收速度常数(Ka)和表观吸收系数(Papp)无显著性影响。结论:艾片的肠吸收机制为被动扩散,其吸收动力学符合一级方程。OBJECTIVE： To investigate the intestinal absorption mechanism of Aipian in rats. METHODS： The rat single-pass intestinal perfusion technique was applied, and the concentration of borneol in Aipian was determined by GC ; the effects of perfusion rate, drug concentration, absorption site on Aipian absorption were studied. RESULTS： The perfusion rate, drug concentration and absorption site had no effect on the absorption rate coefficient （Ka） and apparent permeability coefficient （Papp）.CONCLUSION： The absorption of Aipian is up to the first-order kinetics and passive transport mechanism.

关 键 词：艾片 气相色谱法 单向灌流法 肠吸收动力学 

分 类 号：R285[医药卫生—中药学] R97[医药卫生—中医学]