HBsAg阳性人群家庭成员中抗-HBs水平观察与研究  

Observation and research of anti-HBs level in family members of HBsAg positive crowd

作　　者：江金伦[1] 陈静[1] 竺稽定[1] 

机构地区：[1]浙江省奉化市疾病预防控制中心,浙江奉化315500

出　　处：《中国卫生检验杂志》2011年第9期2261-2262,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的:通过对HBsAg阳性人群家庭成员中大于15岁HBsAg阴性成员进行抗-HBs水平的定量检测,了解其免疫前后抗-HBs水平的变化,为慢性HBV感染者人群密切接触者免疫预防与控制和成人乙肝疫苗免疫策略提供重要的科学依据。方法:采用微粒子酶免疫分析技术(MEIA)[1]。结果:2010年对我市的两个自然村HBsAg阳性人群家庭成员中大于15岁HBsAg阴性成员共30人进行了抗-HBs水平的定量检测,其中免疫前<10 mIU/ml 8人,占26.7%;10 mIU/ml～50 mIU/ml 9人,占30.0%;50 mIU/ml～100 mIU/ml 7人,占23.3%;>100 mIU/ml 6人,占20.0%;平均GMT为112.48 mIU/ml;免疫后<10 mIU/ml 1人,占3.3%;>100 mIU/ml 29人,占96.7%;平均GMT为712.51 mIU/ml。结论:经过乙肝疫苗的接种后,抗-HBs水平都呈明显的上升,因而HBsAg阳性人群家庭成员可通过接种乙肝疫苗来预防与控制HBsAg阳性人群通过水平或性传播等方式造成家庭成员的HBV的感染。Objective： To understand the anti-HBs level change before and after immunization through the quantitative detection of anti-HBs in negative members aged under 15 years old among the HBsAg positive crowd and provide scientific basis for immune prevention and control on those who have close contact with chronic HBV infected people,as well as adult HB vaccine immunity.Methods： Microparticle enzyme immunoassay（MELA） was adopted.Results： 30 HBsAg negative members under 15 years old from HBsAg positive crowd of 2 villages were conducted this detection.The result showed that before immunization,8 cases were 10 mIU/ml,accounting for 26.7%;9 cases were between 10 mIU/ml^50 mIU/ml,accounting for 30.0%;7 cases were between 50 mIU/ml^100 mIU/ml,accounting for 23.3%;6 cases were 100 mIU/ml,accounting for 20.0% and average GMT is 112.48 mIU/ml;while after immunization,1 case was 10 mIU/ml,accounting for 3.3%;29 cases were 100 mIU/ml,accounting for 96.7% and average GMT is 712.51 miU/ml.Conclusion： Anti-HBs level increased obviously after HB vaccine inoculation,which can be taken as an effective way to prevent and control HBV infection for those family members of HBsAg positive crowd.

关 键 词：HBsAg阳性人群家庭成员 乙肝疫苗 抗-HBs水平的定量检测 

分 类 号：R512.62[医药卫生—内科学]