生物材料表面性能调控骨髓间充质干细胞分化  

Modulating the Differentiation of BMSCs by Surface Properties of Biomaterials

作　　者：王玮[1] 李博[1] 高长有[1] 

机构地区：[1]教育部高分子合成与功能构造重点实验室浙江大学高分子科学与工程学系,杭州310027

出　　处：《化学进展》2011年第10期2160-2168,共9页Progress in Chemistry

基　　金：国家自然科学基金项目(No.20934003);国家重点基础研究发展计划(973)项目(No.2011CB606203)资助

摘　　要：结合细胞和生物可降解支架的组织工程和再生医学技术为组织、器官的修复和再生提供了一种新途径。骨髓间充质干细胞(BMSCs)具有多向分化潜能,因其取材简单、来源广泛、增殖能力强,无伦理争议,免疫排斥反应小而备受关注。BMSCs在特定区域定向分化成为靶细胞是干细胞治疗的一个重要前提,尤其受到生物材料表面正负电荷、亲疏水和不同的拓扑结构的影响。材料表面涂层蛋白或接枝多肽能够促进BMSCs的分化能力,而生物材料不同的机械性能、几何形状也会影响BMSCs的分化方向。本文综述了近期生物材料调控BMSCs分化的研究结果,为基于BMSCs的组织工程和再生医学材料的设计提供借鉴和指导。Tissue engineering and regenerative medicine uses seed cells and biodegradable scaffolds to realize tissue regeneration.Interactions between the cells,especially the stem cells,biomaterials take a pivotal factor in regulating structures and functions of the regenerated tissues.Recent focus has been moving to bone marrow mesenchymal stem cells（BMSCs） in terms of biomedical applications because of their ease of isolation and expansion,multipotency and low immunogenicity.However,in order to better utilize their therapeutic potentials it is extremely important to stimulate the desired differentiation while avoid undesired differentiation.The differentiation of BMSCs is regulated by the cell microenvironment or niche.Meanwhile,the biomaterials acted as the carriers or scaffolds of BMSCs with different properties will have a great impact on their differentiation,and in some cases control the fate of BMSCs.The surface charge,hydrophilicity and hydrophobicity as well as surface morphology have an ability to define the differentiation of BMSCs to osteoblasts or chondrocytes.A surface coating or grafting technique is employed to promote the differentiation of BMSCs to targeted cells.More recent results show that the differentiation of BMSCs is also induced by viscoelasticity and geometry of the biomaterials.This article reviews the recent progress in BMSCs differentiation governed by different properties of biomaterials,which may provide a reference to design the scaffolds for accommodation and applications of BMSCs in regenerative medicine.

关 键 词：生物材料 表面界面 再生医学 骨髓间充质干细胞 分化 

分 类 号：TB34[一般工业技术—材料科学与工程] Q28[生物学—细胞生物学]