尖锐湿疣鳞状细胞癌变6例临床病理分析  

Clinical and pathological analysis of 6 cases condyloma acuminatum with squamous cell carcinom

作　　者：李志清[1] 杜琼[2] 董丹丹[3] 潘宁[1] 

机构地区：[1]四川省人民医院皮肤病性病研究所,四川成都610072 [2]四川省人民医院检验科,四川成都610072 [3]四川省人民医院病理科,四川成都610072

出　　处：《淮海医药》2011年第6期499-500,共2页Journal of Huaihai Medicine

摘　　要：目的分析尖锐湿疣鳞状细胞癌变的临床病理特点,以提高诊断水平。方法对6例尖锐湿疣继发鳞状细胞癌变病例的临床和组织病理资料进行分析。结果 6例患者临床表现为龟头或外阴尖锐湿疣久治不愈,HPV基因亚型检测4例为高危型16/18型,病理组织切片显示,Ki-67强阳性表达,P53蛋白高表达。结论有慢性迁延病史的尖锐湿疣患者,结合病理组织检查和分子生物学检测有助于判断有无鳞状细胞癌变。Objective To study the clinical and pathological characteristics of the condyloma acuminatum with squamous cell carcinoma.Methods Clinical characteristics,expression of Ki-67,P53 and distribution of subtypes of HPV-DNA were used to study the condyloma acuminatum with squamous cell carcinoma.Results The 6 analyzed cases had longer clinical history.Four of them had high positive rates of HPV-DNA（type16/18）.All of them had high expression of Ki-67 and P53 in the condyloma acuminatum with squamous cell carcinoma.Conclusion Clinical history,HPV-DNA and expression of P53 and Ki-67 are critical for the diagnosis of condyloma acuminatum with squamous cell carcinoma.

关 键 词：乳头瘤病毒 尖锐湿疣 癌 鳞状细胞 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]