阻塞性睡眠呼吸暂停低通气综合征患者血清晚期氧化蛋白产物水平的变化  

Change of serumal advanced oxidation protein products in patients with obstructive sleep apnea-hyperpnoea syndrome

作　　者：刘伟 刘慧红[2] 张成[2] 于学勇[2] 王瑞玲[2] 

机构地区：[1]山东兖矿集团第三医院,山东济宁272072 [2]济宁医学院附属医院,山东济宁272029

出　　处：《现代中西医结合杂志》2011年第30期3794-3795,共2页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的检测阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者体内晚期氧化蛋白产物(AOPP)水平,探讨其对OSAHS患者易患心血管疾病的作用机制。方法对OSAHS患者和健康对照组进行多导睡眠监测。次晨采空腹静脉血,分光光度计法检测血清AOPP。结果 AOPP水平在轻度、中度、重度OSAHS组患者均高于正常对照组(P<0.05或0.01);相关分析显示AOPP与呼吸暂停低通气指数(AHI)呈正相关(r=0.32,P<0.01)。结论体内AOPP水平升高可能是OSAHS患者易患高血压、冠心病等心血管疾病的机制之一。Objective It is to examine the levels of advanced oxidation protein products with obstructive sleep apnea-hyperpnoea syndrome（OSAHS）,and approach the role of advanced oxidation protein products（AOPP） in development of cardiovascular diseases for patients with OSAHS.Methods Patients with OSAHS and healthy people were made a diagnosis by polysomnograms.Fasting serum AOPP levels were measured in OSAHS patients and healthy people by using spectrophotometer.Results The serum levels of AOPP in OSAHS group were higher than those of control group（P0.05 or 0.01）.AOPP was directly correlated with apnea hyponea index（AHI）（r=0.32,P0.01）.Conclusion The ascending of AOPP in OSAHS patients is the possible pathogenesis of cardiovascular diseases for patients with OSAHS.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 晚期氧化蛋白产物 

分 类 号：R332.2[医药卫生—人体生理学]