多廿烷醇与阿托伐他汀治疗高脂血症的疗效对比  

Therapeutic effect of policosanol and pravastatin on hyperlipidemia:A comparative study

作　　者：孙静[1] 武强[1] 龙梅[1] 

机构地区：[1]解放军总医院国际医学中心,北京100853

出　　处：《军医进修学院学报》2011年第10期1023-1024,1029,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的评价多廿烷醇治疗高脂血症的疗效。方法比较多廿烷醇组(试验组42例,多廿烷醇10mg/d)和阿托伐他汀组(对照组49例,阿托伐他汀10mg/d)的降脂疗效和不良反应发生情况。结果经过16周治疗,两组总胆固醇(TC)、低密度脂蛋白胆固醇(LDL)、高密度脂蛋白胆固醇(HDL-C)较治疗前均有统计学差异(P<0.05)。两组调脂疗效在TC、LDL-C降低方面无明显差异(P>0.05),在降低甘油三酯(TG)方面阿托伐他汀组优于多廿烷醇组。不良反应方面多廿烷醇组(4.7%)明显少于阿托伐他汀组(17.5%)。两组不良反应较轻微,不需停药。结论多廿烷醇10mg/d的降脂效果与阿托伐他汀10mg/d的疗效相当,均能明显降低TC、LDL-C及升高HDL-C。多廿烷醇的安全性优于阿托伐他汀,不良反应轻微,耐受性好。Objective To evaluate the effect of policosanol on hyperlipidemia.Methods Ninety-one patients were divided into policosanol group（n=42） and atorvastatin group（n=49）.Patients in policosanol group were treated with policosanol（10mg/d） and those in atorvastatin group were treated with atorvastatin（10mg/d）.Therapeutic effect and adverse reactions of the two drugs were observed.Results The levels of total cholesterol（TC） and low density lipid-C（LDL-C） were lower while the level of high density lipid-C（HDL-C） was higher 16 weeks after treatment than before treatment in two groups（P0.05）.No significant difference was observed in TC and LDL-C between the two groups（P0.05）.The effect of atorvastatin was better than that of policosanol on triglyceride（TG）.The incidence of adverse reactions was lower in policosanol group than in atorvastatin group（4.7% vs 17.5%）.Since the adverse reactions were mild in the two group,it was not necessary to withdraw the drugs.Conclusion The lipid-reducing effect of policosanol and policosanol（10mg/d） is similar.Both policosanol and policosanol can significantly decrease TC,LDL-C,and increase HDL-C.The safety of policosanol is better than that of atorvastatin.The adverse reactions of policosanol are mild and can be well tolerated.

关 键 词：多廿烷酵 阿托伐他汀 高脂血症 

分 类 号：R543[医药卫生—心血管疾病]