1-乙酰基-3-(2-羟基-4,6-二甲氧基苯基)-5-芳基-2-吡唑啉的合成及Cu^(2＋)荧光探针行为  

Synthesis of 1-Acetyl-3-(2-hydroxyl-4,6-dimethoxyphenyl)-5-aryl-2-pyrazoline and Their Applications as Fluorescent Sensors for Cu^(2+)

作　　者：杨安博[1] 吴婧[1] 徐助雄[1] 王炳祥[1] 

机构地区：[1]江苏省生物功能材料重点实验室,江苏省生物医药功能材料工程研究中心,南京师范大学化学与材料科学学院,南京210097

出　　处：《高等学校化学学报》2011年第10期2306-2310,共5页Chemical Journal of Chinese Universities

基　　金：江苏省自然科学基金(批准号:BK2008435);江苏省高校优势学科建设工程资助项目资助

摘　　要：设计合成了6个1-乙酰基-3-(2-羟基-4,6-二甲氧基苯基)-5-芳基-2-吡唑啉化合物4a～4f.测试了它们的紫外光谱和荧光光谱,研究了其对铜离子的选择性识别作用.结果表明,化合物4f作为铜离子荧光探针,受常见离子干扰较小,对于铜离子有着较高的选择性和较低的检出限.Copper plays an important role in various physiologic processes.The design and synthesis of chemosensors for copper ions has become a very active area of research.The synthetic Cu2＋ selective fluoroionophores so far reported suffer from low sensitivity and,in general,higher concentrations of interfering metal ions disturb the selectivity towards Cu2＋.Here we report the synthesis of six 1-acetyl-3-（2-hydroxyl-4,6-dimethoxylphenyl）-5-aryl-2-pyrazoline（4a—4f） and the studies of them as fluorescent sensors for Cu2＋ ion.The structures of all the products were determined by IR,MS,1H NMR and elemental analysis.Their UV and fluorescence spectra were measured.The influences of eight metal ions such as Cu2＋,Zn2＋,Ni2＋,Co2＋,Na＋,Al3＋,Cd2＋,Ca2＋ and Mn2＋on their fluorescence properties were studied.Spectroscopic studies revealed that the compounds 4a—4f had rather strong affinity toward Cu2＋.The specificity of the probes 4f toward Cu2＋ were determined.Nearly no fluorescence intensity changes were observed in emission spectra with Zn2＋,Ni2＋,Co2＋,Na＋,Al3＋,Cd2＋,Ca2＋ and Mn2＋.However,under identical conditions,the results showed fluorescence quenching with Cu2＋.So we have developed an new fluorescent sensor 4f.It shows high sensitivity and selectivity toward Cu2＋ in DMSO.

关 键 词：1-乙酰基-3-(2-羟基-4 6-二甲氧基苯基)-5-芳基-2-吡唑啉 CU2+ 荧光探针 

分 类 号：O626.21[理学—有机化学]