昆布多糖对家兔血小板聚集和释放的影响  

Effect of Thallus Laminariae Polysaccharides on Platelet Aggregation and Release Reaction in Rabbits

作　　者：曾惠芬[1] 徐露[2] 

机构地区：[1]南方医科大学附属小榄医院,广东中山528415 [2]重庆医科大学药学院.重庆市生化与分子药理重点实验室,重庆400016

出　　处：《中国药业》2011年第19期7-8,共2页China Pharmaceuticals

基　　金：广东省中山市医学科学技术研究基金;项目编号:2010102

摘　　要：目的观察昆布多糖对家兔血小板聚集和释放的影响。方法采用体内试验,比浊法观察昆布多糖对血小板活化因子(PAF)诱导的家兔血小板聚集作用的影响,双抗夹心放射免疫法测定血浆血小板颗粒膜蛋白(GMP-140)含量。结果昆布多糖能抑制血小板活化因子诱导的家兔血小板聚集,与生理盐水组相比有显著差异(P<0.05或P<0.01),并能降低血小板颗粒膜蛋白含量(P<0.01)。结论昆布多糖具有抗血小板活化因子诱导的血小板聚集作用,能抑制血小板的聚集和释放。Objective To investigate the effect of thallus laminariae polysaccharides（TLP） on platelet aggregation and release reaction in rabbits.Methods We observed the effect of TLP on platelet aggregation which was induced by PAF in rabbits in vivo study,using turbidimetry,and determined GMP-140 in plasma using double antibody sandwich method.Results Compared with the saline group,TLP inhibited PAF-induced platelet aggregation were significantly different（P 0.05,P 0.01）,and can reduce the content of GMP-140（P 0.01）.Conclusion TLP could resistant PAF-induced platelet aggregation and release.

关 键 词：昆布多糖 抗血小板聚集 二磷酸腺苷 血小板颗粒膜蛋白 

分 类 号：R285.5[医药卫生—中药学] R282.77[医药卫生—中医学]