奥美拉唑预防脑出血并发消化道出血和顽固性呃逆108例  

Omeprazole for Preventing Intracerebral Hemorrhage Complicating Gastrointestinal Hemorrhage and Intractable Hiccup

作　　者：杨开华[1] 王飞[1] 冉启山[1] 耿世经[1] 文远超[1] 李航[1] 

机构地区：[1]遵义医学院第三附属医院神经外科,贵州遵义563000

出　　处：《中国药业》2011年第19期79-80,共2页China Pharmaceuticals

摘　　要：目的探讨应用奥美拉唑预防脑出血并发消化道出血和顽固性呃逆的可行性。方法医院2007年7月至2009年7月收治格拉斯哥评分(GCS评分)3～11分的184例脑出血患者,入院后即开始预防用药,分组给予奥美拉唑或甲氰咪胍治疗,对比观察各自的临床疗效及预后。结果 108例使用奥美拉唑的患者中,出现消化道出血8例(7.41%),顽固性呃逆3例(2.78%);76例使用甲氰咪胍的患者中,出现消化道出血21例(27.63%),顽固性呃逆10例(13.16%)。结论早期使用奥美拉唑可有效预防脑出血后消化道出血和顽固性呃逆的发生,值得临床推广。Objective To evaluate the feasibility of omeprazole for preventing intracerebral hemorrhage complicating gastrointestinal hemorrhage and intractable hiccup.Methods A hundred and eighty-four inpatients with intracerebral hemorrhage（Glasgow score 3-11） in our hospital from July 2007 to July,2009 treated by the preventive medication after admission were grouped and given omeprazole and cimetidine respectively.The clinical curative effects and prognosis were observed and compared between the two groups.Results In 108 cases using omeprazole,gastrointestinal hemorrhage appeared in 8 cases（7.41%） and intractable hiccup in 3 cases（2.78%）,while in 76 cases using cimetidine,gastrointestinal hemorrhage appeared in 21 cases（27.63%） and intractable hiccup in 10 cases（13.16%）.Conclusion Early use of omeprazole can effectively prevent the occurrence of gastrointestinal hemorrhage and intractable hiccup after intracerebral hemorrhage,which is worthy of clinical popularization.

关 键 词：奥美拉唑 脑出血 预防 消化道出血 顽固性呃逆 

分 类 号：R969.4[医药卫生—药理学] R975.2[医药卫生—药学]