瑰及乳膏抗皲裂效果及皮肤通透性探讨  

Experimental study on the effects of GuiJi cream in anti-fissure and permeability of skin

作　　者：王刚[1] 程晓莉[1] 张幼林[1] 张秀华[1] 常明泉[1] 李炯[1] 李涛[1] 杨光义[1] 

机构地区：[1]湖北医药学院附属太和医院药学部,十堰442000

出　　处：《国际中医中药杂志》2011年第10期890-892,共3页International Journal of Traditional Chinese Medicine

基　　金：湖北医药学院附属太和医院基金项目（项目编号：2009D30）

摘　　要：目的探讨瑰及乳膏治疗皮肤皲裂症的疗效及其皮肤通透性。方法①用健康日本大耳白兔建立皲裂模型，将6只日本大耳白兔裸露背部划分为6块区域，分别对应瑰及乳膏高剂量组（给药量相当于含白及生药0．2g／m吃）、瑰及乳膏中剂量组（相当于含白及生药0．1g／mq）、瑰及乳膏低剂量组f相当于含白及生药0．05g／m1）、尿素霜组（0．1g／m-2）、生理盐水组（等量的生理盐水）和空白对照组进行抗皲裂试验。每天均匀涂抹药物于对应区域，观察并记录皮肤表面皲裂症状改善情况。②36只昆明种小鼠进行皮肤通透性试验，受试前24h背部脊椎两侧对称去毛后，按随机数字表法分为空白对照组、尿素霜组（0．2g／m12）和瑰及乳膏组（0．2g／m-2）各12只。每组涂抹对应药物于背部脊椎两侧，观察各组小鼠腹腔毛细血管通透性和二甲苯致炎耳肿胀度指标。结果①抗皲裂效果：瑰及乳膏高、中、低剂量组用药后疗效评分为3．8～4．2，三个剂量组分别与空白对照组比较，差异均有统计学意义（P均〈0．05）。②尿素霜组、瑰及乳膏组对小鼠耳肿胀抑制率分别为70．0％、75．O％，小鼠耳廓肿胀明显轻于空白对照组（P〈0．05）。尿素霜组、瑰及乳膏组的毛细血管通透性抑制率26．89％、45．08％，与空白对照组比较，抑制小鼠腹腔毛细血管通透性作用增加（P〈0．05）。结论中剂量瑰及乳膏具有抗皮肤皲裂、抗炎效果。Objective To study the effect of Guiji cream in the treatment of fissure and permeability of skin. Methods The models of fissure Japonic rabbits were established to observe the effects of skin cream on inhibiting fissure. Rabbits back area was divided into 6 blocks and given different medicines in six different groups： GuiJi cream group of low dosage, middle dosage and high dosage （0.05, 0.1, 0.2 g/m-2 crude drug of Bletilla colloid respectively）, urea frost cream group （0.1 g/m-2）, normal saline group and control group. Observe the changes of skin surface symptoms every day. The permeability test was performed on 36 KM mouse and randomly divided into control group, GuiJi cream group and urea frost cream group （0.2 g/m-2）. Apply drugs to the back and observe the permeability change of cilia capillary, and auricle swelling degree in mice of each group. Results The curative criteria for Guiji groups was 3.8-4.1, the inhibition rate of auricular swelling was 75%. GuiJi cream could inhibit xylene-induced ear edema （P〈0.05） ; the Inhibition rate of vascular permeability was 45.08%, The ear swelling induced by xylene and increased capillary permeability induced by acetic acid in mice were inhibited significantly （P〈0.05） by Guiji cream which had obvious effects on fissure as well as the permeability. Conclusion Guiji chapped skin cream played significant functions in treating fissure and acting anti-inflammatory.

关 键 词：瑰及乳膏 抗皲裂效果 皮肤通透性 

分 类 号：R285.5[医药卫生—中药学]