3种不同施加因素建立实验性贫血模型的基础研究  

Different Treatment factors on Establishment of Experimental Anemic Animal Models

作　　者：范颖[1] 初杰[1] 赵友林[2] 林庶茹[1] 

机构地区：[1]辽宁中医药大学方剂学科,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《中华中医药学刊》2011年第10期2173-2175,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：辽宁省科技厅资助项目(20062068);辽宁省教育厅资助项目(2007T116)

摘　　要：目的:通过考察3种不同施加因素制作的实验性贫血动物模型外周血细胞计数和血红蛋白含量变化,了解3种不同因素的对机体造成"血虚"的差异性,为临床用药提供科学依据。方法:采用血细胞计数法测定外周血红细胞和白细胞计数以及血红蛋白含量的变化。结果:失血性贫血外周血红细胞计数降低明显(P>0.05),而外周血白细胞计数虽有下降趋势,但无统计学意义(P>0.05);化疗性贫血外周血红细胞计数、白细胞计数均降低(P<0.05),但白细胞计数降低尤为明显(P<0.01),饮食失调组外周血红、白细胞计数均呈下降趋势,但无统计学意义(P>0.05)。结论:3种不同施加因素对机体外周血细胞计数的影响具有差异性。Objective:To analysis the peripheral hemogram variation of three different treatment factors on experimental anemic animal models,realizing the difference in blood deficiency caused by the treatment factors and providing scientific guideline for clinic.Methods:Peripheral blood erythrocytes,peripheral blood leucocytes and hemoglobin were measured by blood count.Results:Peripheral blood erythrocytes mainly decreased in hemorrhagic anemia,peripheral blood leucocytes in chemotherapy-induced Anemia(P>0.01).The amount of peripheral blood erythrocytes tended to be decreased(P>0.05),and peripheral blood leucocytes decreased obviously in eating disorder,(P>0.05).Conclusion:There is difference in three different treatment factors on peripheral hemogram of experimental anemic animal models.

关 键 词：饮食失调 失血 化疗 贫血 造模方法 

分 类 号：R556[医药卫生—血液循环系统疾病]