心肌梗死支架术后丹红注射液抗血小板疗效观察  

Observation of curative effect of the antiplatelet therapy of danhong injection among patients with acute myocardial infarction after percutaneous coronary stent implantation

作　　者：蒋一鸣 俎德玲[1] 诸葛毅[2] 屠晓鸣[1] 周建英[3] 金奇志[1] 程科云[1] 郑家胜[1] 杨庆业[1] 高珍艳[1] 徐红青[1] 

机构地区：[1]浙江省衢州市人民医院心血管内科,浙江衢州324000 [2]浙江衢州职业技术学院医学院,浙江衢州324000 [3]浙江大学医学院第一附属医院呼吸科,浙江杭州310003

出　　处：《中华中医药学刊》2011年第10期2281-2283,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省科技计划资助项目(2007C33010)

摘　　要：目的:探讨急性心肌梗死患者支架术后丹红注射液的抗血小板疗效。方法:急性心肌梗死患者42例支架术后常规治疗的同时,以丹红注射液抗血小板治疗,观察疗效,比较急性心肌梗死(AMI)患者治疗前后和同期40名健康体检者(对照组)血浆血小板活化因子水平。结果:急性心肌梗死支架术42例患者症状消失,治疗前血浆的血小板活化因子水平为(131.34±22.17)μg/L,明显高于对照组(40.69±11.26)μg/L。AMI组经治疗后血浆血小板活化因子水平为(74.59±16.17)μg/L,明显降低(P<0.01)。结论:AMI血小板处于活化状态,血小板活化因子可作为冠心病病情监测的有效指标,丹红注射液的抗血小板治疗有效,有助于提高急性心肌梗死患者支架术效果。Objective： To investigate the antiplatelet therapeutic effect of danhong injection for the patients with acute myocardial infarction（AMI） after percutaneous coronary stent implantation.Methods： The effect of antiplatelet therapy of danhong injection and conventional therapy meanwhile among 42 cases of patients hospitalized with acute myocardial infarction after percutaneous coronary stent implantation and 40 healthy subjects over the same period（control group） were investigated.The change of plasma levels of platelet activating factor among those patients and control group were observed and test data was compared.Results： Symptoms disappeared among 42 cases of patients hospitalized with acute myocardial infarction after percutaneous coronary stent implantation after antiplatelet therapy of danhong injection.The plasma levels of platelet activating factor in subject group before treatment was（131.34±22.17）μg/L,after treatment was（74.59±16.17）μg/L,in control group was（40.69±11.26）μg/L,which were much higher than those of the controls（P0.01） respectively.The evidence shows a statistical significance difference that the plasma levels of platelet activating factor in subject group before the treatment is higher than those after the treatment（P0.01）.Conclusion： Due to platelet activation in AMI,the plasma levels of platelet activating factor can be used as effective indicators of coronary heart disease monitoring.It is useful by antiplatelet therapy of danhong injection for patients with acute myocardial infarction after percutaneous coronary stent implantation and effective for enhancement of curative effect with percutaneous coronary stent implantation.

关 键 词：急性心肌梗死 经皮冠状动脉支架植入术 血小板活化因子 丹红注射液 

分 类 号：R542.2[医药卫生—心血管疾病]