三黄散瘀巴布剂抗炎镇痛研究  

Pharmacodynamics Study on Sanhuang Sanyu Cataplasm

作　　者：刘云飞[1] 尹华[1] 章建华[2] 许丛辉[1] 

机构地区：[1]浙江中医药大学药学院,浙江杭州310053 [2]浙江中医药大学附属第一医院,浙江杭州310006

出　　处：《中华中医药学刊》2011年第10期2310-2312,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省科技厅重点科技计划项目(2007C23020);浙江省中药现代化专项资金;浙江省中医药科研基金资助项目(2006C038)

摘　　要：目的:研究三黄散瘀巴布剂的抗炎镇痛作用。方法:制备低、中、高剂量的三黄散瘀巴布剂,观察不同剂量三黄散瘀巴布剂对二甲苯所致小鼠耳肿胀和10%蛋清所致大鼠足趾肿胀的抗炎作用;观察不同剂量三黄散瘀巴布剂对小鼠醋酸扭体和小鼠热板法的作用。结果:三黄散瘀巴布剂对10%蛋清所致大鼠足趾肿胀和二甲苯所致小鼠耳肿胀有明显的抑制作用(P<0.05);能明显减少由醋酸引起的小鼠扭体次数,可显著提高小鼠的痛阈值(P<0.05)。结论:三黄散瘀巴布剂具有较好的抗炎、镇痛作用。Objective： To investigate the pharmacodynamics effects of Sanhuang Sanyu Cataplasm.Methods： To observe the anti-inflammatory effects of Sanhuang Sanyu Cataplasm on mice ear edema induced by xylene and the rat paw edema induced by 10% egg-white and the effects of Sanhuang Sanyu Cataplasm on mice writhing induced by acetic acid and licking feet by the hot plate.Results： Sanhuang Sanyu Cataplasm can significantly inhibit mice ear edema induced by xylene and the rat paw edema induced by 10% egg-white,it also can significantly reduce the acetic acid induced writhing in mice and increase the pain threshold of mice.Conclusion： Sanhuang Sanyu Cataplasm has good anti-inflammatory and analgesic effects.

关 键 词：三黄散瘀巴布剂 药效学 抗炎 镇痛 

分 类 号：R285.5[医药卫生—中药学]