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机构地区:[1]河北省唐山市中医医院
出 处:《中西医结合心脑血管病杂志》2011年第10期1153-1154,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基 金:河北省中医药管理局2009年度科研课题计划基金项目(No.2009221)
摘 要:目的观察益气化瘀冲剂试验性治疗慢性收缩性心力衰竭的临床疗效及安全性。方法将240例慢性收缩性心力衰竭患者随机分为两组。试验组120例口服益气化瘀冲剂,每日1剂(1袋),分为早晚两次服用;对照组120例口服安慰剂(颗粒冲剂),每日1剂(1袋),分早晚两次服。两组试验期间均以常规西药抗心力衰竭为基础治疗,2个月为1个试验疗程,然后评估两组疗效。结果两组治疗2个月后,试验组在心功能、左室射血分数、下肢水肿指标的改善方面与对照组比较均有统计学意义(P<0.05);在气虚血瘀证候改善方面,试验组与对照组总有效率分别为95.7%和53.1%,试验组优于对照组(P<0.05)。结论在常规西药治疗的基础上加用益气化瘀中药,是慢性收缩性心力衰竭治疗的有效选择,且具有安全性。初步证实慢性收缩性心力衰竭的发生与中医气虚血瘀病机具有相关性。Objective To observe relation between chronic systolic heart failure and pathogenesis of qi deficiency and blood stasis syndrome.Methods Two hundreds and forty patients with cardiac function Ⅱ to Ⅲ grade(LVEF≤40%) were randomly divided into two groups:Treatment group(n=120) treated by Yiqi Huayu granules,and control group(n=120) treated with oral placebo for 2 months.The effects,adverse reactions and toxicity were assessed.Results Following treatment for 2 months,the heart function,left ventricular ejection fraction,lower extremity edema index in treatment group were improved significantly compared with that in control group(P0.05).The total effective rate in improvement of qi deficiency and blood stasis syndrome was 95.7% and 53.1% in two groups respectively(P0.05).Conclusion Yiqi Huayu granules was effective and safety for chronic systolic heart failure.The chronic systolic heart failure were related to the pathogenesis of qi deficiency and blood stasis syndrome.
分 类 号:R259[医药卫生—中西医结合]
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