单次高负荷量阿托伐他汀对PCI围术期心肌标志物的影响  

Influence of Single High Loading Dose of Atorvastatin on Periprocedural Myocardial Markers

作　　者：李馨[1] 刘云宝[1] 黄超联[1] 苗立夫[1] 李莉娜[1] 孙晓艳[1] 

机构地区：[1]北京华信医院,100016

出　　处：《中西医结合心脑血管病杂志》2011年第10期1180-1182,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的观察经皮冠状动脉介入(PCI)治疗前服用80 mg阿托伐他汀能否降低围术期心肌标志物水平。方法将行择期PCI的87例冠心病患者随机分为两组,高剂量组予冠心病基础药物治疗,并在PCI前8 h内给予单次高负荷剂量(80 mg)阿托伐他汀;对照组仅予基础药物治疗。PCI后24 h检测两组肌钙蛋白T(TnT)、肌酸激酶同工酶(CK-MB)、C反应蛋白(CRP)水平。结果术后高剂量组TnT、CRP水平显著低于对照组(P<0.05);高剂量组术后TnT升高大于正常上限3倍者显著少于对照组(0 vs11.1%,P<0.05)。结论对于稳定型心绞痛及心肌标志物水平正常的不稳定型心绞痛患者,介入术前给予单次80 mg阿托伐他汀能显著降低围术期心肌标志物水平。Objective To investigate whether loading 80 mg atorvastatin prior to percutaneous coronary intervention（PCI） could efficiently reduce the incidence of periprocedural myocardial infarction.Methods A total of 87 patients with coronary artery disease who underwent selective PCI were enrolled and randomized into two groups：Atorvastatin group given a single loading of 80 mg atorvastatin within 8 hours before receiving PCI,and the control group treated with routine medication alone.TnT,CK-MB,and CRP were checked in all patients within 24 hours after PCI.Results Post-operative TnT and CRP levels in atorvastatin group were significantly lower than those in control group（P0.05）.The patients with TnT level 3 times above the normal value in atorvastatin group was significantly less than that in control group（0 vs 11.1%,P0.05）.Conclusion The level of myocardial markers and corresponding incidence of myocardial infarction might be reduced by a single high loading dose of 80 mg atorvastatin given prior PCI in stable angina patients and unstable angina patients with normal myocardial markers.

关 键 词：冠心病 经皮冠状动脉介入术 阿托伐他汀 心肌标志物 

分 类 号：R541.4[医药卫生—心血管疾病]