BOLD—fMRI和DTI结合神经导航在枕叶视觉功能区附近病变切除中的应用  

Application of BOLD - fMRI and DTI on the treatment of lesions in or surrounding the occipital visual function area undergoing the neuronavigation

作　　者：孙胜玉[1] 马辉[1] 王晓东[2] 黄伟[1] 张伟[2] 夏鹤春[1] 

机构地区：[1]宁夏医科大学附属医院神经外科,银川750004 [2]宁夏医科大学附属医院放射科,银川750004

出　　处：《中华神经外科杂志》2011年第9期925-928,共4页Chinese Journal of Neurosurgery

基　　金：宁夏自治区科技攻关资助项目（2008-165-17）;2008年度宁夏自然科学基金项目（NZ08121）

摘　　要：目的探讨血氧水平依赖性功能磁共振成像（BOLD—fMRI）与磁共振弥散张量成像技术（DTI）融合结合神经导航在枕叶视觉功能区附近病变切除术中的应用价值。方法利用BOLD—fMRI、DTI结合神经导航进行图像融合，在20例视觉功能区附近病变患者术前设计手术入路，术中定位视觉功能区，指导手术，合理保护功能区，切除病变。结果15例镜下全切除，5例大部切除。术后复查MRI及DTI视皮层及视辐射保护完好。结论BOLD—fMRI和DTI融合技术在神经导航下应用可以准确确定大脑枕叶视觉功能区和视辐射走行，术前精确定位功能区，提高病变切除程度，降低术后致残率，提高患者术后生活质量。Objective To evaluate the value of BOLD -fMRI and DTI in the operations of lesions in or surrounding the occipital visual function area. Method 20 patients with brain lesions adjacent to the occipital visual function area were obtained by block design. Visual cortex activation function imaging was obtained by BOLD -fMRI technique and optical radiation tracts imaging was obtained by DTI. All function imaging and anatomic imaging were transferred to the neuronavigation system. Surgical approach was designed before the surgery. Occipital visual functional area was located, guided and protected during the operation. The lesion was resected under the microscope. Results Total lesion resection was achieved in 15 cases, subtotal resection in 5 cases. Visual functions were improved or unchanged in 18 cases, temporary worsen in 2 cases. The visual functions using the BOLD -fMRI and DTI were protected intact after operation. Conclusions With the assistant of neuronavigation, the combination of the BOLD - fMRI and DTI was helpful for resecting the lesion in or surrounding the occipital visual function, and was useful to decrease the side effect injury and improve the life quality.

关 键 词：磁共振成像 弥散张量成像 视觉功能区 神经导航 

分 类 号：R651.1[医药卫生—外科学]