腰椎置管治疗隐球菌性脑膜炎4例并文献复习  

Lumbar drainage catheter for the treatment of cryptococcal meningitis:4 case reports and literature review

作　　者：雷文知[1] 杨雅骊[1] 刘晓刚[1] 都琳[1] 陈裕充[1] 陈江汉[1] 顾菊林[1] 温海[1] 

机构地区：[1]上海长征医院皮肤病与真菌病研究所上海市医学真菌分子生物学重点实验室全军真菌病重点实验室中国医学真菌保藏管理中心隐球菌专业实验室,上海200003

出　　处：《中国真菌学杂志》2011年第4期216-219,共4页Chinese Journal of Mycology

基　　金：国家自然科学基金(81071335)

摘　　要：目的观察早期腰椎置管引流加鞘内注射两性霉素B治疗伴有恶性高颅压隐球菌性脑膜炎的临床效果及探讨临床应用的可行性。方法详细分析和归纳整理了我科应用腰椎置管法治疗的4例隐球菌性脑膜炎患者的临床资料。结果 4例患者经早期腰椎置管引流加鞘内注射两性霉素B治疗后临床症状迅速改善。经联合治疗后,痊愈3例,好转1例,4例患者随访至今均无复发。结论早期腰椎置管引流加鞘内注射两性霉素B治疗隐球菌性脑膜炎能有效的降低隐球菌脑膜炎患者的高颅压,改善临床症状,提高疗效。Objective To observe the effect of lumbar drainage catheter and intrathecal injection of amphotericin B on the early treatment of cryptococcal meningitis,and to investigate the clinical feasibility.Methods Clinical data of 4 patients with cryptococcal meningitis under lumbar drainage catheter treatment was collected and analyzed.Results After early treatment of lumbar drainage catheter and intrathecal injection of amphotericin B,3 patients were cured without recurrence and the other one was significanly improved.Conclusions Lumbar drainage catheter combined with intrathecal injection of amphotericin B in early treatment of cryptococcal meningitis is efficient in the reduction of high CSF pressure and the improvement of clinical symptoms.

关 键 词：隐球菌性脑膜炎 腰椎置管 鞘内注射 

分 类 号：R379.5[医药卫生—病原生物学]