PI3K信号通路对T细胞发育、活化、增殖、分化及支气管哮喘的作用  

Role of PI3K signal in development, activation, differentiation of T cell and bronchial asthma

作　　者：聂颖[1] 李昌崇[1] 

机构地区：[1]温州医学院附属育英儿童医院呼吸科,325027

出　　处：《国际呼吸杂志》2011年第19期1466-1470,共5页International Journal of Respiration

基　　金：基金项目：浙江省自然基金资助项目（Y2090327）;浙江省大学生科技创新活动计划（新苗人才计划）资助项目（2010R413044）

摘　　要：T细胞是参与支气管哮喘发病的重要效应细胞，而磷脂酰肌醇－3－激酶（P13K）是T细胞的重要信号转导分子。P13K信号通过影响双阴性细胞的B－选择而影响T细胞的成熟，还通过激活PKB、Rac等信号途径而参与T细胞的活化、分化。同时，P13K通过参与Th1／Th2失衡的调节，嗜酸粒细胞、肥大细胞的黏附、脱颗粒等而参与支气管哮喘气道炎症反应。T lymphocyte is the core cell in the bronchial asthma. The phosphoinositide3-kinase （PI3K） pathway is the important signal transduction pathway in the T lymphocyte. PI3K signaling plays a role in the development of T cells through affecting the double-negative cells of the Q-selection, and T cell activation and differentiation through activation of PKB, Rac and other signaling pathway. At the same time, PI3K signal also involved in the airway inflammation of asthma including the regulation of Thl/Th2 imbalance, adhesion, degranulation of eosinophils and mast cells.

关 键 词：PI3K信号 T细胞 发育 分化 哮喘 

分 类 号：R562.25[医药卫生—呼吸系统]