子宫肌瘤围手术期抗菌药物使用管理效果分析  

Management of antibiotics application during perioperative period of uterine fibroids:efficacy analysis

作　　者：叶文君[1] 黄琴香[1] 

机构地区：[1]温州医学院附属温岭医院内科,浙江温岭317500

出　　处：《中华医院感染学杂志》2011年第19期4124-4125,共2页Chinese Journal of Nosocomiology

摘　　要：目的了解医院妇科对卫生部办公厅《关于进一步加强抗菌药物临床应用管理的通知》执行情况。方法随机抽取2007年1-6月(对照组)和2010年1-6月(观察组)各105例子宫肌瘤手术患者病历,对其围手术期抗菌药物使用情况进行回顾性调查。结果对照组和观察组围手术期抗菌药物使用率均为100.00%;首次给药在术前30 min^2 h、术后抗菌药物平均使用时间及联合用药率对照组和观察组比较,差异有统计学意义(P<0.05);抗菌药物选择种类构成比对照组与观察组相比,硝基咪唑类从41.83%下降至26.57%、头孢菌素类从38.25%下降至33.57%、氟喹诺酮类从16.33%下降至0、而青霉素类从0上升至31.47%。结论子宫肌瘤围手术期抗菌药物选用及首次给药时机把握日趋规范,而术后抗菌药物使用时间的管理有待于进一步加强。OBJECTIVE To understand the implementation of the standards of antibiotic usages from the Ministry of Health,in gynecological hospital.METHODS From Jan to Jun 2007,the uterine myoma surgery patient records of 105 cases were randomly selected as control group and 105 cases from Jan to Jun 2010 were selected as study group,and the perioperative use of antimicrobial agents were investigated retrospectively.RESULTS The use rates of antimicrobial agents in control group and observation group during perioperative period were 100.00%（P0.05）;first administration in the preoperative 0.5-2 h,after antibiotic combination therapy,the average time and combination use rate were compared,the differences were statistically significant（P0.05）;species composition of selected antimicrobial agents and the observation group than the control group compared to nitroimidazole decreased from 41.83% to 26.57%,cephalosporins decreased from 38.25% to 33.57%,fluoroquinolones from 16.33% to 0,and penicillin increased from 0 to 31.47%.CONCLUSION Uterine fibroids perioperative administration of antimicrobial selection and timing for the first time is increasingly standardized,but the management of use time needs to be further strengthened.

关 键 词：子宫肌瘤 围手术期 抗菌药物 干预 效果 

分 类 号：R978.1[医药卫生—药品]