ATP-MgCl_2对兔主动脉条收缩反应的影响  

Effect of ATP-MgCl_2 on Contraction of Rabbit Aortic Strips

作　　者：吴祯久 曲香芝[1] 张红英[1] 金松哲[1] 张世杰[1] 李柱天[1] 姜文天 

机构地区：[1]延边医学院药理学教研室 [2]延吉市制药一厂

出　　处：《延边医学院学报》1990年第2期106-109,共4页Journal of Medical Science Yanbian University

摘　　要：ATP-MgCl_2和维拉帕米(Ver)抑制去甲肾上腺素(NE)和KCl所致兔主动脉条收缩反应,使量-效曲线非平行右移,压低最大收缩反应,说明是非竞争性拮抗,而单纯ATP和单纯MgCl_2的拮抗作用不明显。ATP-MgCl_2和Ver选择性抑制电压依赖性钙通道(PDC),抑制细胞内Ca^(++)的释放,但对受体启动性钙通道(ROC)的抑制作用不明显。单纯ATP和单纯MgCl_2的作用均不如ATP-MgCl_2和Ver。The effects of ATP-MgCl_2, simple ATP and MgCl_2 on the contraction induced by norepinephrine(NE) or KCI were studied on the rabbit aortic strips, and the calcium antagonist verapamil(Ver)was used for comparison. ATP-MgCl_2 or Ver inhibited the contractions evoked by NE or KCI; they shifted dose-response curves for NE or KCI to the right in a non-parallel fashion, and depressed their maximal responses, showing noncompetitive antagonism. While in the ATP or MgCl_2 group, there were no apparent changes. ATP-MgCl_2 or Ver inhibited selectively potential-dependent Ca^(2+)channel (PDC). Both ATP-MgCl_2 and Ver inhibited the release of intracellular Ca^(2+), but had no influence on inhibiting action of receptoroperated Ca(2+) channel(ROC); the action of the former was more potent than that in the ATP group and MgCl_2 group. This shows that both ATPMgCl_2 and Ver block the release of calcium from intracellular storage.

关 键 词：ATP-MGCL2 主动脉条 收缩反应 

分 类 号：R965[医药卫生—药理学]