联合应用地塞米松、甲氧氯普胺预防妇科腹腔镜手术后恶心、呕吐的临床研究  

Clinical study of combined application of dexamethasone,metoclopramide in postoperative nausea and vomiting in gynecological laparoscopic operation

作　　者：蔡小丽[1] 徐志新[2] 何春华[3] 

机构地区：[1]新疆医科大学第五附属医院麻醉科,新疆乌鲁木齐830011 [2]新疆医科大学第一附属医院麻醉科,新疆乌鲁木齐830011 [3]新疆医科大学医学工程技术学院麻醉学基础教研室,新疆乌鲁木齐830011

出　　处：《新疆医科大学学报》2011年第8期889-891,共3页Journal of Xinjiang Medical University

摘　　要：目的探讨术前联合应用地塞米松和甲氧氯普胺对妇科腹腔镜手术后恶心、呕吐的预防作用。方法 120例行妇科腹腔镜探查手术患者均采用相同的静脉快速诱导,气管内插管全身麻醉。采用双盲法,随机分为4组,A组在全麻诱导前静脉注射地塞米松10 mg,B组在全麻诱导前静脉注射甲氧氯普胺20 mg,C组在全麻诱导前静脉注射地塞米松10 mg+甲氧氯普胺20 mg,O组为对照组,在全麻诱导前静注生理盐水4 ml,观察记录术后0～3 h,3～6 h,6～12 h及12～24 h 4组恶心、呕吐的发生情况。结果术后不同时间段A、B、C组恶心、呕吐发生次数均明显优于O组,差异有统计学意义(P<0.05～0.01)。A、B组和C组比较,在不同时间段恶心、呕吐的发生次数差异有统计学意义(P<0.05)。结论术前联合应用甲氧氯普胺和地塞米松对预防妇科腹腔镜手术后恶心、呕吐效果确切。Objective To preoperative and postoperative effects of combined with dexamethasone,metoclopramide after gynecologic laparoscopic surgery nausea and vomiting prevention.MethodsAll patients were treated with the same rapid intravenous induction of general anesthesia endotracheal intubation.Used double-blind methods,the patients were randomized into 3 groups,before induction of anesthesia,A group were given dexamethasone 10 mg in intravenous,B group were given metoclopramide 20 mg in intravenous,C group were given dexamethasone 10 mg＋metoclopramide 20 mg in intravenous,O group as a control group,were given normal saline 4 ml before induction of anesthesia.24 hours after operation,the four groups of nausea and vomiting were observed and recorded.ResultsPostoperative A,B,C groups were nausea,vomiting occurrence frequency,were significantly better than the O group,there were statistically significant（P0.05）.A,B group and C group had a significant difference（P0.05）.ConclusionMetoclopramide and dexamethasone can prevent nausea and vomiting after gynecological laparoscopic surgery.

关 键 词：地塞米松 甲氧氯普胺 腹腔镜手术 恶心 呕吐 

分 类 号：R713[医药卫生—妇产科学]