溃结宁膏穴位贴敷治疗脾肾阳虚型溃疡性结肠炎临床疗效及其对血清白细胞介素-4的影响  

Clinical Efficacy of Acupoint Paste of Kuijiening Plaster in Treating Spleen-Kidney Yang Deficiency Syndrome of Ulcerative Colitis and Its Effect on Serum IL-4 Level

作　　者：余莹[1] 朱莹[2] 

机构地区：[1]湘潭职业技术学院,湖南湘潭411102 [2]湖南中医药大学第二附属医院,湖南长沙410005

出　　处：《中国中医药信息杂志》2011年第10期11-13,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：湖南省中医药科研计划(2009005);长沙市科技计划(K0902133-31)

摘　　要：目的观察溃结宁膏穴位贴敷治疗脾肾阳虚型溃疡性结肠炎(UC)的临床疗效及其对血清白细胞介素-4(IL-4)的影响。方法选取60例脾肾阳虚型慢性复发型UC活动期患者,随机分为治疗组和对照组各30例,分别给与溃结宁穴位贴敷及口服柳氮磺胺吡啶治疗60 d,观察治疗前后2组临床综合疗效、黏膜病变疗效、黏膜病理疗效、中医证候疗效、血清IL-4的变化及不良反应等情况。结果治疗组中医证候疗效优于对照组(P<0.05);2组临床综合疗效、黏膜病变及黏膜病理疗效相当(P>0.05);治疗后治疗组和对照组IL-4水平均明显高于治疗前(P<0.05),且治疗组与对照组比较差异有统计学意义(P<0.05)。结论溃结宁膏穴位贴敷能提高脾肾阳虚型慢性复发型UC的临床疗效,减轻临床症状,减少不良反应,提高机体免疫力。Objective To observe the therapeutic effect of acupoint paste of Kuijiening Plaster in treating spleen-kidney Yang deficiency syndrome of ulcerative colitis（UC） patients and the effect of serum IL-4 level.Methods Sixty cases of spleen-kidney Yang deficiency syndrome of chronic relapsing UC in active stage were randomly divided into the treatment group and the control group,with 30 cases in each group,and were given Kuijiening point paste and oral SASP treatment respectively for 60 days.The clinical comprehensive efficacy,mucosal lesions efficacy,mucosal pathological efficacy,TCM curative effects,the main symptom efficacy,serum IL-4 and side effects were observed.Results The TCM curative effects in treatment group were better than control group（P0.05）.The comprehensive clinical efficacy,the efficacy of mucosal lesions and mucosal pathology were equivalent between the two groups（P0.05）.There was significant difference in the serum IL-4 between before and after treatment in both groups（P0.05）,and between the two groups（P0.05）.Conclusion The acupoint paste of Kuijiening Plaster can improve clinical efficacy of spleen-kidney Yang deficiency syndrome of UC,relieve symptoms,reduce side effects and improve immunity.

关 键 词：溃结宁膏 穴位贴敷 溃疡性结肠炎 脾肾阳虚 白细胞介素-4 

分 类 号：R259.746.2[医药卫生—中西医结合]