血管回声跟踪技术评价辛伐他汀干预家兔动脉粥样硬化  

Study on the evaluation of artery elasticity in simvastatin intervention rabbits with atherosclerosis by echo-tracking technique

作　　者：冉小芳[1] 刘福林[1] 周程[1] 赵金惠[2] 许金鹏[1] 胡娇娇[1] 

机构地区：[1]河北大学附属医院心血管外科,河北保定071000 [2]河北大学附属医院超声科,河北保定071000

出　　处：《医学研究与教育》2011年第4期9-13,37,共6页Medical Research and Education

基　　金：河北省2007年医学科学研究重点课题计划项目(07134)

摘　　要：目的利用血管回声跟踪技术评价辛伐他汀干预家兔动脉粥样硬化的研究。方法健康新西兰大耳白兔共18只,随机分为普通饲料喂养的正常组、对照组(腹主动脉球囊拉伤+高脂饲料喂养)及实验组(腹主动脉球囊拉伤+高脂饲料喂养+辛伐他汀干预治疗)。在模型建立后,ET技术检测动脉僵硬度,综合评估血管弹性。结果 (1)对照组与正常组相比,Eρ、β、AI、PWVβ明显增高,AC明显减小,具有统计学意义(P≤0.05)。实验组与正常组相比,则只有AC、AI差异具有统计学意义(P≤0.05)。实验组与对照组比较,Eρ、β、AI、PWVβ具有统计学意义(P≤0.05),AC无明显统计学意义。各项参数中,Eρ、β、PWVβ较其他参数差异更为显著(P≤0.01)。(2)相关性分析:对五个参数的相关性进行分析,发现参数β、Eρ、AI和PWVβ呈正相关(P≤0.05),其中β、Eρ、PWVβ三者相关性更为显著(P≤0.01);虽然AC随Eρ、β、PWVβ、AI增高而减小,但AC与各参数相关性并不显著(P>0.05)。结论血管弹性参数改变可以较为准确灵敏的反映血管病变,能够为预防动脉硬化及相关疾病的发生提供可靠依据,对动脉硬化的早期诊断具有重要意义。可利用该技术对药物疗效以及预后、转归等进行检测评估,向临床各领域扩展应用。Objective To evaluate the artery elasticity of abdominal aorta in simvastatin intervention rabbits with atherosclerosis by echo-tracking（ET） technique.Methods Eighteen healthy New Zealand rabbits were divided into three groups randomly： no-treated group（bred by ordinary animal feeds）,control group（established atherosclerosis model by femoral artery angioplasty）and Simvastatin-treated group.The stiffness of abdominal aorta of every rabbit was evaluated by Echo-Tracking at the end of the study.Results（1）The differences about the indicator of pressure-strain elasticity modulus（Eρ）,the stiffness parameter（β）,argumentation index（AI）,one-point pulse wave velocity（PWVβ）,arterial compliance（AC） between the no-treated group and the control group were significant（P0.05）.There were significant differences in AC,AI between the Simvastatin-treated group and the no-treated group（P0.05）.To compare the Simvastatin-treated group and the control group,the differences in Eρ、β、AI、PWVβ were statistically significant（P0.05）,but AC was not.It was found that Eρ、βand PWVβ were significant higher than the others（P0.01）.（2） Correlation analysis： PWVβ correlated negatively with Eρ、βand AI.The correlation was significant at the 0.05 level.Correlation between Eρ、βand PWVβ was significant at the 0.01 level.Although AC decreased when Eρ、β、AI、PWVβ increased,the correlation was not significant（P0.05）.Conclusion（1） The indexes of the artery elastic can reflect the pathological changes accurately.It may be helpful to prevent and diagnose atherosclerosis and other relevant arteries disease.（2） ET can evaluate the curative effect of drugs,and provide important information on prognosis and turnover.

关 键 词：动脉粥样硬化 血管回声跟踪技术 兔 

分 类 号：R1[医药卫生—公共卫生与预防医学]