1-甲基-吡唑-3-羧酸的合成研究  

Research on the Synthesis of 1-methyl-pyrazole-3-carboxylic Acid

作　　者：张正[1] 李孝琼[1] 杨盟辉[1] 段远富[1] 田应仟[1] 

机构地区：[1]中国人民解放军61699部队,湖北武汉430070

出　　处：《广州化工》2011年第18期72-73,96,共3页GuangZhou Chemical Industry

摘　　要：以3-甲基吡唑为原料,通过氧化和甲基化反应两步反应得到1-甲基-吡唑-3-羧酸,总收率32.2%。考察了反应时间、反应温度、物料配比等条件对产率的影响,优化了反应条件,并用红外光谱和液相色谱对目标化合物进行了表征。1-methyl-pyrazole-3-carboxylic acid was synthesized using 3-methylpyrazole as raw material by twostep reaction of oxidation and methylation in 32.2% total yield.The effects of reaction time,reaction temperature and ratio of materials were investigated and optimized.The structure of target compound was confirmed by IR spectrum and liquid chromatography.

关 键 词：1-甲基-吡唑-3-羧酸 氧化 甲基化 合成 

分 类 号：TQ440.4[化学工程—化学肥料工业]