调脂通脉汤对动脉粥样硬化大鼠血脂、血液流变学的影响  

Effect of Tiaozhi Tongmai Tang on Fat and Hemorheology Of Fats with Atherosclerosis

作　　者：张凤华[1] 周峰[2] 楚溪[3] 张俊芳[4] 张晓静[1] 郭秋红[1] 张建平[1] 梁文杰[1] 

机构地区：[1]河北医科大学,石家庄050091 [2]河北石家庄市第一医院,石家庄050001 [3]河北医科大学第四医院,石家庄050051 [4]河北工程大学附属医院,邯郸056029

出　　处：《河北中医药学报》2011年第3期3-5,2,共3页Journal of Hebei Traditional Chinese Medicine and Pharmacology

基　　金：河北省科技厅科研基金项目:No10276105D-8

摘　　要：目的:探讨调脂通脉汤对动脉粥样硬化(AS)大鼠血脂、血液流变学的影响。方法:将60只雄性W istar大鼠随机分为5组:空白对照组、模型组、阳性对照药辛伐他汀组及调脂通脉汤高、低剂量组。采用腹腔注射维生素D加高脂喂饲的方法复制AS大鼠模型。灌胃给予辛伐他汀组及高、低剂量的调脂通脉汤,连续4周。实验结束时取血检测血脂及血液流变学相关的指标。结果:模型组血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)明显高于空白对照组,而高密度脂蛋白(HDL)明显高于模型组,差异有非常显著性(P<0.01);辛伐他汀组及调脂通脉汤高、低剂量组血清TC、TG、LDL均低于模型组,而HDL明显高于模型组,差异有显著性(P<0.05,P<0.01)。血液流变学实验结果显示,模型组大鼠较正常对照组全血黏度(全血低切、全血高切)、血浆黏度、变形指数、红细胞比容均明显增高,血沉明显加快,差异有非常显著性(P<0.01);辛伐他汀组及调脂通脉汤高、低剂量组较模型组全血黏度、血浆黏度、变形指数、红细胞比容均明显降低,血沉明显减慢,差异有显著性(P<0.05,P<0.01)。结论:调脂通脉汤能降低AS大鼠血脂水平,降低全血黏度和血浆黏度而发挥抗AS作用。Objective: to explore the effect of Tiaozhi Tongmai Tang(TTT) on the blood fat and haemorheology of AS rats.Methods: 60 male Wistar rats were randomly divided into 5 groups: control group,model group,positive Simvastatin group,high dose of TTT group and low dose group.AS model rats were made by intraperitoneal injection of vitamin D and high fat diet.TTT were given to Simvastatin,high and low dose groups by intragastric administration for 4 weeks,followed by detecting the indexes of blood fat and hemorheology.Results: TC,TG and LDL of model group were obviously higher than those of control group while HDL was lower with significant difference(P<0.01);TC,TG and LDL of Simvastatin,high and low dose groups were lower than those of control group while HDL was obviously lower with significant difference(P<0.05,P<0.01).Hemorheology experiment showed that,compared to control group,whole blood viscosity,plasma viscosity,deformation index,RBC specific volume increased and blood sedimentation fastened obviously with significant difference(P<0.01);whole blood viscosity,plasma viscosity,deformation index,RBC specific volume of Simvastatin,high and low dose groups decreased and blood sedimentation sloweded obviously with significant difference(P<0.05,P<0.01).Conclusion: TTT can reduce the blood fat,whole blood and plasma viscosity of AS rats and has the function of resisting AS.

关 键 词：调脂通脉汤 动脉粥样硬化 血脂 血液流变学 大鼠 

分 类 号：R285.5[医药卫生—中药学]