盐酸羟考酮控释片直肠给药控制癌痛的临床观察  

Clinical observation of oxycodone hydrochloride controlled-release tablets for moderate and severe cancer pain by rectal administration

作　　者：宋志刚[1] 庞东生[1] 

机构地区：[1]海军安庆医院肿瘤内科,安徽安庆246003

出　　处：《西部医学》2011年第10期1922-1923,1926,共3页Medical Journal of West China

摘　　要：目的观察盐酸羟考酮控释片(奥施康定)直肠给药治疗晚期癌症患者中、重度疼痛的临床效果、不良反应及患者的生活质量的改善情况。方法对23例癌痛患者采取直肠给药的方式,观察治疗前后的镇痛效果、不良反应及生活质量评分。结果 23例中、重度癌痛患者治疗2周后完全缓解(CR)11例,部分缓解(PR)9例,显著有效率为87.0%,平均镇痛起效时间80min,平均镇痛时间11.7h,治疗前平均KPS评分(36.09±8.39),治疗后(61.30±10.14),生活质量较前明显改善。不良反应主要为便秘。结论对于不能口服给药的患者,盐酸羟考酮控释片直肠给药具有良好的镇痛效果,不良反应少,程度轻,并能明显提高患者的生活质量。Objective To observe the clinical effects and the adverse effects of oxycodone hydrochloride controlled-release tablets（oxycontin） by rectal administration in the treatment of moderate and severe pain in patients with terminal cancer and to observe any improvement on living quality of the cancer patients.Methods 23 patients suffering from moderate and severe cancer pain were treated with oxycodone hydrochloride controlled-tablets by rectal administration.The analgesic effects,karnofsky performance status scales（KPS） and adverse effects were observed.Results Among all the 23patients suffering from moderate and server cancer pain,11 achieved CR,9 achieved PR,and effective rate was 87.0%.The mean onset time of analgesic effect was 80 min,and the mean duration of analgesic effect was 11.7 h.Additionally,the karnofsky mark after treatment which was 61.30±10.14 was higher than before which was 36.09±8.39.The quality of life was significantly improved after treatment.Main effect was constipation.Conclusion The oxycodon hydrochloride controlled-release tablets by rectal administration can effectively control cancer pain.The adverse effects are mild and slight,and the drug can significantly improve the living quality for patients with cancer pain.

关 键 词：盐酸羟考酮控释片 癌痛 直肠给药 

分 类 号：R452[医药卫生—治疗学]