慢性乙型肝炎伴凝血因子Ⅶ缺乏1例并文献复习  

A case of chronic hepatitis B with coagulation factor Ⅶ deficiency

作　　者：蔡少平[1] 何卫平[1] 张文瑾[1] 范振平[1] 吉英杰[1] 高峰[1] 史雪敏[1] 

机构地区：[1]解放军第302医院军人肝病诊疗中心,北京市100039

出　　处：《实用肝脏病杂志》2011年第5期338-339,共2页Journal of Practical Hepatology

摘　　要：目的复习慢性乙型肝炎合并遗传性凝血因子Ⅶ缺乏的特点。方法分析1例慢性乙型肝炎伴遗传性凝血因子Ⅶ缺乏症患者的临床资料,并复习相关文献。结果该患者PT明显延长,FⅦ活性降低,而APTT及其他凝血因子活性均正常,HBV标记物阳性,而肝功能指标正常。结论遗传性凝血因子Ⅶ缺乏症是临床上一种非常少见的出血性疾病,多伴有基因缺陷,目前尚无根治的方法。对于慢性乙型肝炎患者PT明显延长而肝功能正常时,应积极查找肝病以外的原因。Objective To report the clinical features of patients with coagulation factor Ⅶ defciency and hepatitis B.Method One patients with chronic hepatitis B and coagulation factor Ⅶ defciency was reported.Result The patients had a prolonged PT and normal APTT,while he had a positive serum hepatitis B markers and normal liver function tests.Conclusion Coagulation factor Ⅶ defciency is a rare hemorrhage disease with some gene defect.A patient with prolonged PT and normal liver functions should be diagnosed carefully.

关 键 词：慢性乙型肝炎 凝血因子Ⅶ缺乏症 凝血酶原时间 

分 类 号：R512.62[医药卫生—内科学]