骨库的特点及发展趋势  

Features and development trends of bone bank

作　　者：丛宪玲[1] 王金成[1] 王亮[1] 高硕徽[1] 孙然[1] 

机构地区：[1]吉林大学中日联谊医院,吉林省长春市130033

出　　处：《中国组织工程研究与临床康复》2011年第33期6235-6238,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:随着供骨来源的增加和相关技术的进步,骨库在全世界逐渐普及。目的:介绍骨库的历史、特点、工艺流程及其发展趋势。方法:应用计算机检索PubMed及CNKI数据库中关于同种异体骨和骨库方面的文献,并进行总结。纳入文章所属内容应与骨库的特点、产生及发展相关,排除重复论述及科研分析相关领域的文章。结果与结论:共检索到185篇文献,排除无关重复的文献,保留18篇文献进行综述。目前研究显示,与环氧乙烷熏蒸相比,辐照灭菌的效果更加理想。同时,国外某些研究发现,非辐照灭菌骨的感染率与辐照灭菌骨相当。小型骨库难以达到美国组织库协会和欧洲组织库协会的审核标准,不断被大型组织库兼并。一套规范化的管理制度和完整的核心技术对于骨库的建立是必需的。在中国,骨库还有很大的提升空间和潜力,有望在医学领域得到更好的发展。BACKGROUND：With increase in bone sources and improvement in related technology,bone bank has been widely accepted all over the world.OBJECTIVE：To introduce the history,features,technical process and development trends of bone bank.METHODS：A computer-based retrieval of PubMed and CNKI database to search the manuscripts regarding bone allograft and bone bank and summarized.Manuscripts that describe the features,formation and development of bone bank were included.Those with repetitive contents,reviews,and scientific analysis were excluded.RESULTS AND CONCLUSION：A total of 185 manuscripts were retrieved.After excluding non-related or repetitive manuscripts,18 manuscripts were included in the final analysis.Compared with epoxyethane fumigation,irradiation sterilization acquires more ideal effects.Meanwhile,some studies abroad showed that the infection rate of non-irradiation sterilized bone were comparable to irradiation sterilized bone.Small-scale bone banks are difficult to achieve the auditing standards of American Association of Tissue Banks and European Association of Tissue Banks,Therefore,they will be merged into large-scale tissue banks.It is necessary to establish a standardized management system and intact core technology in bone banks.Bone bank has a great potential to well develop,and it is expected to achieve a better development in medical application.

关 键 词：骨库 同种异体骨 辐照灭菌骨移植 发展趋势 骨组织工程 

分 类 号：R318[医药卫生—生物医学工程]