间质成纤维细胞α-SMA与乳腺癌的关系  

The Relations Between α-SMA Expression in Interstitial Fibroblasts and Breast Cancer

作　　者：张岩[1] 徐继[1] ZHANG Yan,XU Ji （Medical Oncology,Lianyungang Second People＇s Hospital,Lianyungang 222023,China）

机构地区：[1]连云港市第二人民医院肿瘤科,江苏连云港222023

出　　处：《医学信息》2011年第20期6775-6776,共2页Journal of Medical Information

摘　　要：目的探讨乳腺癌间质成纤维细胞α-平滑肌肌动蛋白在乳腺癌浸润机制中的作用。方法通过免疫组化的方法检测α-SMA在乳腺癌及正常乳腺组织间质中的表达。结果α-SMA在原位癌及浸润性导管癌问质成纤维细胞阳性表达率分别为18．2％（2／11），78．1％（25／32），两者有统计学意义（P〈0．01）。结论α-SMA与乳腺癌浸润机制有一定关系，Objective To research α-SMA of interstitial fibroblasts action in the mechanism of the role of invasive breast cancer as well as the relationship between the prognosis of breast cancer. Methods By immunohistochemistry to detect α-SMA in breast cancer and normal breast tissue expression of interstitial. Results α-SMA in interstitial fibroblasts of DCIS and the invasive ductal carcinoma positive expression rate was 18.2%（2/ 11 ）and 78.1%（25/32）,between the two was statistically significant（P〈0.01）.Conclusion α-SMA and breast cancer invasion mechanisms have a certain relationship.

关 键 词：Α-SMA 成纤维细胞 乳腺癌 

分 类 号：R697.320.2[医药卫生—泌尿科学;医药卫生—临床医学;医药卫生—外科学]