综合措施治疗高血压合并胰岛素抵抗  

The clinical therapeutic effect of combined therapy to hypertensive patient combined with insulin resistance

作　　者：周向东[1] 万大国[2] 

机构地区：[1]郑州市第三人民医院心内科,河南郑州450000 [2]郑州大学第二附属医院心内科,河南郑州450014

出　　处：《河南医学研究》2011年第3期300-302,共3页Henan Medical Research

摘　　要：目的:观察综合措施治疗高血压合并胰岛素抵抗的疗效。方法:选择我院2007年5月至2010年5月门诊及住院的肥胖型轻中度高血压患者132例,随机分为A组(64例)、B组(68例),A组给予替米沙坦每日80 mg,硝苯地平缓释片20 mg,2次/d,B组除控制饮食、减轻体重外,针对伴有的物质代谢紊乱采取综合治疗措施。治疗2月后观测空腹血糖、糖化血红蛋白、体质指数变化。结果:治疗后,2组患者的SBP、DBP均较治疗前下降,B组降压效果明显优于A组(P<O.05)。2组患者的空腹血糖、糖化血红蛋白、体质指数治疗前后比较,B组明显优于A组,(P<0.05)。结论:药物降压同时,针对伴有的物质代谢紊乱采取综合治疗措施,既能有效降压,又能减轻体重,同时还能改善肥胖患者体内代谢紊乱状态,是一种行之有效的方法。Objective：To observe the clinical therapeutic effect of combined therapy to hypertensive patient combined with insulin resistance（IR）.Methods：A total of 132 cases of hypertensive patients in-patient and out-patient complicated with IR from the year of February,2007 to May 2011 in our hospital,which were randomly divided into two groups,64 persons in group A,68 persons in group B.Group A was treated with telmisartan and nifedipine,while group B was treated with telmisartan and nifedipine,also with combined therapy of decreasing food and controling body weight.Results：The total efective rate（95.6%）in B group was significantly higher than A group（65.6%）.There were statistical significance in diference between two groups（P0.05）.After treatment,systolic blood pressure,diastolic blood pressure decreased significantly.Statistical significance was noted in diference before and after treatment（P0.05）.After treatment,BMI,FPG,HbA1C of group B decreased ignificantly.Statistical significance was noted in diference between two groups（P0.05）.Conclusion：Medicine combined with combined therapy of decreasing food and controling body weight was beneficial to hypertensive patient combined with IR.

关 键 词：高血压 胰岛素抵抗 替米沙坦 硝苯地平 

分 类 号：R544.1[医药卫生—心血管疾病]