肉桂油与肉桂水提物对虚寒证模型大鼠的药理作用及其数理分析  

Pharmacological effects of Oleum Cinnamomi and water extract of Cortex Cinnamomi in rats with yang-deficiency cold syndrome and the mathematical analysis

作　　者：张倩[1] 张冰[1] 金锐[1] 李连珍[1] 赵茜[1] 刘小青[1] 

机构地区：[1]北京中医药大学中药学院,北京100029

出　　处：《中西医结合学报》2011年第9期983-990,共8页Journal of Chinese Integrative Medicine

基　　金：国家重点基础研究发展计划(973计划)资助项目(No.2007CB512605)

摘　　要：目的:采用生物学与数理分析相结合的方法,比较分析肉桂油及肉桂水提物对虚寒状态大鼠的影响,探讨肉桂不同提取物药性表达的异同。方法:雄性Sprague-Dawley大鼠48只,分为正常组、模型组、肉桂油组和肉桂水提物组。以氢化可的松琥珀酸钠肌肉注射建立大鼠虚寒模型,并分别给予肉桂油和肉桂水提物,检测其物质代谢指标如葡萄糖(glucose,GLU)、尿酸(uric acid,UA)、总胆固醇(total cholesterol,TC)、三酰甘油(triacylglycerol,TAG)、总蛋白(total protein,TP)、白蛋白(albumin,ALB),能量代谢指标如血清乳酸(lactic acid,LAC)和乳酸脱氢酶(lactate dehydrogenase,LDH)以及肝匀浆琥珀酸脱氢酶(succinate dehydrogenase,SDH)和腺嘌呤核苷三磷酸酶(adenosine triphosphatase,ATPase),内分泌系统指标如血清皮质类固醇(corticosteroid,CS)、三碘甲腺原氨酸(triiodothyronine,T3)、甲状腺素(tetraiodothyronine,T4)、促甲状腺激素(thyroid sti mulatinghormone,TSH)、雌二醇(estradiol,E2)、维生素C(vitamin C,VC)和血浆17-羟皮质类固醇(17-hydroxycorticosteriod,17-OHCS),免疫系统相关指标如免疫球蛋白M(i mmunoglobulinM,IgM)、免疫球蛋白G(i mmunoglobulin G,IgG)、补体C3(complement3,C3)和补体C4(complement4,C4),并引入数理分析方法对结果进行比较分析。结果:肉桂油和肉桂水提物对于虚寒状态大鼠物质代谢、能量代谢、内分泌、免疫系统的部分指标具有相同的影响趋势,表现为纠正作用的GLU、TC、TAG、TP、ALB、IgM、E2、CS、VC、17-OHCS和加重作用的UA、C3;对于IgG、C4、T3、T4和ATPase,二者表现为相反的影响趋势;在TSH、LAC、SDH等指标上肉桂水提物的作用不明显,而肉桂油的影响较大;对于ATPase、LDH、IgG等指标肉桂水提物的作用则更大。结论:肉桂油与肉桂水提物对虚寒状态大鼠生化指标的作用呈现出复杂相关性。二者药性表达相似,但在一定程度上仍有所差异,其具体机制仍需进一步探�Objective： To compare the effects of Oleum Cinnamomi and water extract of Cortex Cinnamomi in rats with yang-deficiency cold syndrome based on mathematical analysis. Methods： A total of 48 male Sprague-Dawley rats were randomly divided into 4 groups （normal, model, Oleum Cinnamomi and water extract of Cortex Cinnamomi）. Yang-deficiency cold syndrome was induced by hydrocortisone sodium succinate. Oleum Cinnamomi and water extract of Cortex Cinnamomi were given by gastrogavage daily for one week to respective groups. Material metabolism indexes such as glucose （GLU）, uric acid （UA）, total cholesterol （TC）, triacylylyceral （TAG）, total protein （TP） and albumin （ALB）; energy metabolism indexes such as lactic acid （LAC）, lactate dehydrogenase （LDH）, succinate dehydrogenase （SDH） and adenosine triphosphatase （ATPase）; endocrine system indexes such as corticosteroid （CS）, triiodothyronine （T3）, tetraiodothyronine （T4）, thyroid stimulating hormone （TSH）, estradiol （E2）, vitamin C （VC） and 17-hydroxycorticosteriod （17-OHCS）; and immune system indexes such as immunoglobulin M （IgM）, immunoglobulin G （IgG）, complement 3 （C3） and complement 4 （C4） were measured. And then the data were analyzed by mathematical analysis method. Results： Oleum Cinnamomi and water extract of Cortex Cinnamomi had similar influence on some indexes of material metabolism, energy metabolism and endocrine and immune systems in rats with yang-deficiency cold syndrome. Positive effects were showed in GLU, TC, TAG, TP, ALB, IgM, E2, CS, VC and 17-OHCS. Water extract of Cortex Cinnamomi had no significant effects on TSH, LAC and SDH, but Oleum Cinnamomi had, while water extract of Cortex Cinnamomi had significant effects on ATPase, LDH and IgG. Conclusion： There is a complex relationship between Oleum Cinnamomi and water extract of Cortex Cinnamomi in their effects on rats with yang-deficiency cold syndrome. They have similar property, however, disparities ex

关 键 词：肉桂 中草药 植物提取物 虚寒 中药性味 数学计算 大鼠 

分 类 号：R285[医药卫生—中药学]