不同CT值的脊柱结核病灶骨中OPG和OPGL的表达  

The expression of OPG and OPGL in the focus of different CT value of spinal tuberculosis

作　　者：何玉泽[1] 王自立[2] 马腾[2] 

机构地区：[1]徐州医学院附属医院,221002 [2]宁夏医科大学附属医院

出　　处：《中国实用医药》2011年第26期21-23,共3页China Practical Medicine

摘　　要：目的通过研究不同CT值的脊柱结核病灶骨中骨保护蛋白(OPG)和骨保护蛋白配体(OPGL)的表达情况以及与平均CT值的关系,揭示OPG和OPGL参与脊柱结核的病理过程,从分子水平深化对脊柱结核病灶骨硬化发生机制的认识。方法用PV-6000二步法免疫组化检测技术测定OPG和OPGL的平均光密度及阳性面积比,并将其比值与平均CT值进行相关分析。结果 OPG和OPGL表达强度的比值与平均CT值呈正相关。结论 OPG和OPGL表达的动态不平衡导致了脊柱结核病灶周围硬化骨的产生。Objective To explain the role of OPG and OPGL in the pathological process of spinal tuberculosis through studying the expression of OPG and OPGL in section of different CT value of spinal tubercular infectious focus. To analyze molecular mechanism of the indurascent focus of spinal tuberculosis. Methods Measured the mean optical density and percent of positive area of OPG and OPGL in the different group by means of PV-6000 two-step immunochemistry technique,while analyzed correlation between their expression and the mean CT value. Results Ratio of expression of OPG and OPGL and the mean CT value was direct correlation. Conclusion The dynamic unbalance of expression of OPG and OPGL led to the creation of ossified bone in spinal tuberculosis.

关 键 词：脊柱结核 OPG OPGL 免疫组化 CT 

分 类 号：R529.2[医药卫生—内科学]