三乙醇乳膏预防鼻咽癌患者放疗皮肤反应的效果  

The effects of trolamine cream on preventing skin-reaction of nasopharyngeal cancer patients with radiotherapy

作　　者：都新俊[1] 王珍[2] 徐宁[1] 冯玉英[3] 张艳敏[1] 王淑英[1] 

机构地区：[1]滨州医学院附属医院肿瘤七病房,滨州256600 [2]滨州医学院附属医院康复疼痛科,滨州256600 [3]滨州医学院附属医院烧伤病区,滨州256600

出　　处：《中华现代护理杂志》2011年第28期3442-3443,共2页Chinese Journal of Modern Nursing

摘　　要：目的观察三乙醇乳膏（比亚芬）预防鼻咽癌放疗后放射性皮肤反应的效果。方法将110例采用直线加速器放疗的鼻咽癌患者随机分为治疗组（n=55）和对照组（n=55），治疗组于第1次放疗后给予比亚芬乳膏涂抹照射野皮肤，对照组只做常规护理，不涂任何药物。观察两组在20Gy、50Gy和70Gy照射剂量时皮肤反应程度。结果治疗组与对照组在20Gy照射剂量时，皮肤反应发生率差异无统计学意义（χ^2=6．25，P〉0．05）；当放疗剂量达到50Gy时，治疗组皮肤反应以Ⅰ度为主，占67．27％，而对照组则以Ⅱ度（45．45％），为主，另有14例出现Ⅲ度皮肤反应，两组间比较差异有统计学意义（x。=16．37，P〈0．01）；当放射剂量达到70Gy时，治疗组仍以Ⅰ，Ⅱ度为主（81．82％），而对照组有70．91％的患者达到Ⅲ度，且有4例因出现极严重的皮肤反应而被迫中止放疗，组间差异具有统计学意义（χ^22=20．57，P〈0．01）。结论比亚芬乳膏能有效地预防鼻咽癌放疗后皮肤反应的发生，能减轻患者痛苦，使放射治疗顺利进行。Objective To observe the effects of trolamine cream（biafine） on preventing nasopharyngeal cancer patients＇ radioactive skin-reaction after radiotherapy. Methods 110 nasopharyngeal cancer patients who use the linear accelerator radiotherapy were divided into the treatment group and the control group stochastically, the treatment group after the first radiotherapy was given trolamine cream to paint the irradiated coverage of skin, the control group only was given conventional nursing without any medicine. Observes two groups when 20 Gy, 50 Gy, the 70 Gy dose the skin-reaction degree, and carries on the contrastive analysis. Results Treatment group and control group when 20 Gy dose, the skin-reaction rate is not remarkable difference, there is no statistical significance（ χ^2 = 6.25, P 〉 0. 05 ） ; While 50 Gy dose, the treatment group skin-reaction responds with degree I （67.27%）, control group with degree II （45.45%）, besides, 14 degree m skin reactions were occurred, there is significantly different（χ^2 = 16.37, P 〈0. 01 ） ; When 70 Gy, treatment group still with I and 11 degree （81.82%）, control group 70.90% with m degree, and 4 examples are forced to stop treatment because of the most serious skin reaction. To compare with control group, the skin-reaction of treatment group is obviously eased and deferred （χ^2 = 20.57, P 〈 0. 01 ）. Conclusions Biafine can prevent skin-reaction of nasopharyngeal cancer patients＇ radioactive skin-reaction after radiotherapy, ease the patient＇ s pain, and make sure radiotherapy go on.

关 键 词：鼻咽肿瘤 放射治疗 放射性皮肤反应 三乙醇乳膏 

分 类 号：R473.73[医药卫生—护理学]