血清内巨噬细胞衍生趋化因子、胸腺和活化调节趋化因子水平与支气管哮喘临床参数的关系  

Relationship of macrophage-derived chemokine and thymus-and activation-regulated chemokine levels in serum and clinical parameter in asthma

作　　者：周艳秋 田颖 高红军 张楠 周云芝 王洪武 

机构地区：[1]煤炭总医院呼吸内科,北京100028

出　　处：《中国医药导报》2011年第28期16-18,共3页China Medical Herald

摘　　要：目的:探讨巨噬细胞衍生趋化因子(macrophage-derived chemokine,MDC)、胸腺和活化调节趋化因子(thymus-and activation-regulated chemokine,TARC)与支气管哮喘密切相关的IgE、白细胞介素-5(IL-5)及外周血嗜酸粒细胞计数(eosinophils,EOS)等临床参数的关系。方法:收集支气管哮喘患者112例(特应性皮炎患者除外)、健康人58例(性别、年龄与支气管哮喘患者相匹配,无特应性皮炎)作对照。应用酶联免疫吸附法检测每例患者非急性发作时血清内MDC、TARC、总IgE、IL-5的浓度及健康人血清中MDC、TARC浓度,测定外周血EOS计数。分别评价支气管哮喘患者血清内MDC、TARC水平与总IgE、IL-5及EOS的关系,评价血清内MDC、TARC水平在支气管哮喘患者与健康人之间的差异性。结果:支气管哮喘患者血清内MDC浓度与总IgE、IL-5水平呈正相关(IgE,r=0.243,P=0.013 0;IL-5,r=0.309,P=0.004 0),MDC、TARC血清内浓度与EOS呈正相关(MDC,r=0.388,P=0.000 1;TARC,r=0.275,P=0.042 2)。支气管哮喘患者非发作时血清内MDC、TARC浓度与健康人之间比较,差异无统计学意义(P>0.05)。结论:MDC、TARC可能是支气管哮喘有价值的临床生物学标志物,在支气管哮喘的发病机制中起着重要作用。Objective： To investigate the relationship of macrophage-derived chemokine（MDC） and thymus and activation regulated chemokine（TARC） levels and total IgE,IL-5,EOS in serum of patients with bronchial asthma.Methods： 112 patients with bronchial asthma and 58 healthy control subjects were included in this study.Serum MDC,TARC protein levels and total IgE,IL-5 levels were measured in patients with bronchial asthma non-outbreak,and MDC,TARC levels were measured in healthy controls by ELISA.The association was analyzed between MDC,TARC levels and serum total IgE,IL-5,EOS in bronchial asthma.The difference of serum MDC,TARC levels was analyzed between the patients with bronchial asthma and healthy controls.Results： Significant association was found between the serum levels of MDC and the concentration of serum total IgE,IL-5 in bronchial asthma and they presented for positive correlations（IgE,r=0.243,P=0.013 0;IL-5,r=0.309,P=0.004 0）.Positive correlations were also found between MDC,TARC and the numbers of EOS in bronchial asthma（MDC,r=0.388,P=0.000 1;TARC,r=0.275,P=0.042 2）.Regrettably,no significant difference was found between patients with bronchial asthma non-outbreak and healthy controls in serum MDC,TARC levels（P〉0.05）.Conclusion： MDC,TARC may be a useful biologic marker and play an important role in the pathogenesis of bronchial asthma.

关 键 词：巨嗜细胞衍生趋化因子 胸腺和活化调节趋化因子 支气管哮喘 

分 类 号：R562.25[医药卫生—呼吸系统]